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E-pub ahead of print

Systematic review on the current knowledge and use of Single-cell RNA Sequencing in Head and Neck Cancer

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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PURPOSE: Single-cell RNA Sequencing (scRNA-seq) is a novel method enabling genetic characterization of tumor tissue at a single-cell level.

METHODS: This study systematically reviewed the literature on studies using scRNA-seq to characterize head and neck squamous cell carcinomas (HNSCC).

RESULTS: Seven studies were included, of which two studies performed scRNA-seq on 20 patients in total, and five studies used scRNA-seq data in a subsequent clinical study. The former mentioned two studies found intra-tumoral genetic heterogeneity among malignant cells but genetic uniformity among non-malignant cells. The five latter studies used scRNA-seq data in various ways. Three studies identified biomarkers related to predicting whether a patient would benefit from immunotherapeutic treatment. One study characterized genes related to the perineural invasion. One study identified genes to be used in diagnostics.

CONCLUSION: Further studies performing scRNA-seq on HNSCC are required to continue the ongoing development and use of scRNA-seq.

OriginalsprogEngelsk
TidsskriftAPMIS - Journal of Pathology, Microbiology and Immunology
ISSN0903-4641
DOI
StatusE-pub ahead of print - 24 sep. 2021

Bibliografisk note

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ID: 67842985