TY - JOUR
T1 - Systematic nurse-led consultations based on electronic patient-reported outcomes for women with endometrial or ovarian cancer during chemotherapy-a feasibility study
AU - Christiansen, Mille Guldager
AU - Pappot, Helle
AU - Jarden, Mary
AU - Tolver, Anders
AU - Mikkelsen, Hjalte Søberg
AU - Mirza, Mansoor Raza
AU - Piil, Karin
N1 - © 2025. The Author(s).
PY - 2025/9/17
Y1 - 2025/9/17
N2 - PURPOSE: This study aimed to investigate the feasibility of nurse-led consultations based on ePRO for women with endometrial or ovarian cancer receiving chemotherapy.METHODS: This was a prospective single-cohort feasibility study. The patients responded to weekly ePRO using the Elekta Kaiku platform, which was adapted to Danish. At selected time points during chemotherapy, nurses conducted nurse-led consultations replacing physicians. The primary outcome was the patient completion rate of ePRO reporting in the Elekta Kaiku platform. Secondary outcomes included assessing safety, acceptability, practicability, usability, patient satisfaction with ePRO, and patient symptom burden.RESULTS: Twenty patients were included, with a mean age of 59 years. A total of 320 ePRO reports were received, equivalent to an ePRO response of 18 times per patient during six cycles of chemotherapy. The results showed a high weekly completion rate (87%), high patient satisfaction with ePRO, and a continuous high symptom burden. Nurse-led consultations achieved a success rate of 55% in adhering to scheduled appointments. The primary contributing factors to this issue were the inadequate internal workflows and the complex symptom burden experienced by the patients.CONCLUSION: This study indicates that weekly ePRO reporting in conjunction with nurse-led consultations may be feasible in this population. The use of ePRO revealed a high level of symptoms reported by patients throughout the treatment cycles. The results emphasize the importance of clinicians in proactively and systematically intervening at an early stage to prevent symptom escalation. However, the small sample size limits the generalizability of this study.TRIAL REGISTRATION: This study was registered at the Capital Region of Denmark (P-2021-179) and approved the 10/03/2021. ClinicalTtrials.gov ID: NTCC04945187.
AB - PURPOSE: This study aimed to investigate the feasibility of nurse-led consultations based on ePRO for women with endometrial or ovarian cancer receiving chemotherapy.METHODS: This was a prospective single-cohort feasibility study. The patients responded to weekly ePRO using the Elekta Kaiku platform, which was adapted to Danish. At selected time points during chemotherapy, nurses conducted nurse-led consultations replacing physicians. The primary outcome was the patient completion rate of ePRO reporting in the Elekta Kaiku platform. Secondary outcomes included assessing safety, acceptability, practicability, usability, patient satisfaction with ePRO, and patient symptom burden.RESULTS: Twenty patients were included, with a mean age of 59 years. A total of 320 ePRO reports were received, equivalent to an ePRO response of 18 times per patient during six cycles of chemotherapy. The results showed a high weekly completion rate (87%), high patient satisfaction with ePRO, and a continuous high symptom burden. Nurse-led consultations achieved a success rate of 55% in adhering to scheduled appointments. The primary contributing factors to this issue were the inadequate internal workflows and the complex symptom burden experienced by the patients.CONCLUSION: This study indicates that weekly ePRO reporting in conjunction with nurse-led consultations may be feasible in this population. The use of ePRO revealed a high level of symptoms reported by patients throughout the treatment cycles. The results emphasize the importance of clinicians in proactively and systematically intervening at an early stage to prevent symptom escalation. However, the small sample size limits the generalizability of this study.TRIAL REGISTRATION: This study was registered at the Capital Region of Denmark (P-2021-179) and approved the 10/03/2021. ClinicalTtrials.gov ID: NTCC04945187.
KW - Humans
KW - Female
KW - Feasibility Studies
KW - Middle Aged
KW - Patient Reported Outcome Measures
KW - Endometrial Neoplasms/drug therapy
KW - Prospective Studies
KW - Ovarian Neoplasms/drug therapy
KW - Aged
KW - Patient Satisfaction
KW - Adult
KW - Denmark
KW - Referral and Consultation
KW - Antineoplastic Agents/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=105016592349&partnerID=8YFLogxK
U2 - 10.1007/s00520-025-09875-y
DO - 10.1007/s00520-025-09875-y
M3 - Journal article
C2 - 40963057
SN - 0941-4355
VL - 33
SP - 858
JO - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
IS - 10
M1 - 858
ER -