Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Systematic Literature Review and Meta-Analysis of the Relationship Between Polyunsaturated and Trans Fatty Acids During Pregnancy and Offspring Weight Development

Publikation: Bidrag til tidsskriftReviewForskningpeer review


  1. What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Development of a Mobility Diet Score (MDS) and Associations With Bone Mineral Density and Muscle Function in Older Adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Phase angle measured by bioelectrical impedance analysis and the risk of cardiovascular disease among adult Danes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Protein Intake During Infancy and Subsequent Body Mass Index in Early Childhood: Results from the Melbourne InFANT Program

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Loss of height predicts total and cardiovascular mortality: a cohort study of northern European women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and trans fatty acids (TFAs) may have an impact on offspring weight development. We conducted a systematic review and meta-analysis according to PRISMA guidelines to evaluate whether levels of these fatty acids during pregnancy influenced offspring weight development. Randomized controlled trials (RCTs) with DHA and/or EPA supplementation or cohort studies, which examined levels of DHA, EPA, or TFAs in maternal or neonatal blood samples and recorded offspring weight, were included. Overall, 27 RCTs and 14 observational studies were identified. The results showed that DHA and/or EPA supplementation doses >650 mg/day resulted in slightly higher birth weight (MD 87.5 g, 95% CI 52.3-122.6, n = 3,831) and combined BMI and BMI z score at 5-10 years (SMD 0.11, 95% CI 0.04-0.18, n = 3,220). These results were rated as moderate quality. Results from the observational studies were generally inconsistent. High TFA levels during pregnancy seemed to be associated with lower birth weight. Finally, this review and meta-analysis supports a relationship between high maternal or neonatal DHA and/or EPA levels and higher offspring birth weight and weight in childhood. More high-quality long-term studies are still needed.

TidsskriftFrontiers in nutrition
Sider (fra-til)625596
StatusUdgivet - 25 mar. 2021

ID: 65750393