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Region Hovedstaden - en del af Københavns Universitetshospital
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Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

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DOI

  1. Effect of apoA-I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Synthesis, Radiolabeling and in Vitro and in Vivo Evaluation of 18F-ENL30: A Potential PET Radiotracer for the 5-HT7 Receptor

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  1. Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study

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  2. Structural brain abnormalities associated with cognitive impairments in bipolar disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

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Vis graf over relationer

The α4/6βδ-containing GABAA receptors are involved in a number of brain diseases. Despite the potential of a δ-selective imaging agent, no PET radioligand is currently available for in vivo imaging. Here, we report the characterization of DS2OMe (1) as a candidate radiotracer, 11C-labeling, and subsequent evaluation of [11C]DS2OMe in a domestic pig as a PET radioligand for visualization of the δ-containing GABAA receptors.

OriginalsprogEngelsk
TidsskriftACS omega
Vol/bind4
Udgave nummer5
Sider (fra-til)8846-8851
Antal sider6
ISSN2470-1343
DOI
StatusUdgivet - 31 maj 2019

ID: 59012636