Synergy of two human endogenous retroviruses in multiple myeloma

Kathrine L M Schmidt; Annette J Vangsted; Bettina Hansen; Ulla B Vogel; N Emil U Hermansen; Sara B Jensen; Magdalena J Laska; Bjørn A Nexø

doi:10.1016/j.leukres.2015.06.014

Synergy of two human endogenous retroviruses in multiple myeloma

Kathrine L M Schmidt, Annette J Vangsted, Bettina Hansen, Ulla B Vogel, N Emil U Hermansen, Sara B Jensen, Magdalena J Laska, Bjørn A Nexø

Afdeling for Blodsygdomme

6 Citationer (Scopus)

Abstract

Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate the risk of MM with endogenous retroviral loci in humans. We used SNP analysis on a Sequenom platform and statistical analysis in SPSS. Markers near two endogenous retroviral loci, HERV-Fc1 on chromosome X and HERV-K on chromosome 1, were associated with MM. Moreover, there was strong gene-gene interaction in relation to risk of MM. We take this as indirect confirmation of the association.

Originalsprog	Engelsk
Tidsskrift	Leukemia Research
Vol/bind	39
Udgave nummer	10
Sider (fra-til)	1125-8
Antal sider	4
ISSN	0145-2126
DOI	https://doi.org/10.1016/j.leukres.2015.06.014
Status	Udgivet - 2015

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10.1016/j.leukres.2015.06.014

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title = "Synergy of two human endogenous retroviruses in multiple myeloma",

abstract = "Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate the risk of MM with endogenous retroviral loci in humans. We used SNP analysis on a Sequenom platform and statistical analysis in SPSS. Markers near two endogenous retroviral loci, HERV-Fc1 on chromosome X and HERV-K on chromosome 1, were associated with MM. Moreover, there was strong gene-gene interaction in relation to risk of MM. We take this as indirect confirmation of the association.",

keywords = "Endogenous Retroviruses/genetics, Epistasis, Genetic, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Multiple Myeloma/genetics, Polymorphism, Single Nucleotide",

author = "Schmidt, {Kathrine L M} and Vangsted, {Annette J} and Bettina Hansen and Vogel, {Ulla B} and Hermansen, {N Emil U} and Jensen, {Sara B} and Laska, {Magdalena J} and Nex{\o}, {Bj{\o}rn A}",

year = "2015",

doi = "10.1016/j.leukres.2015.06.014",

language = "English",

volume = "39",

pages = "1125--8",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Pergamon",

number = "10",

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TY - JOUR

T1 - Synergy of two human endogenous retroviruses in multiple myeloma

AU - Schmidt, Kathrine L M

AU - Vangsted, Annette J

AU - Hansen, Bettina

AU - Vogel, Ulla B

AU - Hermansen, N Emil U

AU - Jensen, Sara B

AU - Laska, Magdalena J

AU - Nexø, Bjørn A

PY - 2015

Y1 - 2015

N2 - Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate the risk of MM with endogenous retroviral loci in humans. We used SNP analysis on a Sequenom platform and statistical analysis in SPSS. Markers near two endogenous retroviral loci, HERV-Fc1 on chromosome X and HERV-K on chromosome 1, were associated with MM. Moreover, there was strong gene-gene interaction in relation to risk of MM. We take this as indirect confirmation of the association.

AB - Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate the risk of MM with endogenous retroviral loci in humans. We used SNP analysis on a Sequenom platform and statistical analysis in SPSS. Markers near two endogenous retroviral loci, HERV-Fc1 on chromosome X and HERV-K on chromosome 1, were associated with MM. Moreover, there was strong gene-gene interaction in relation to risk of MM. We take this as indirect confirmation of the association.

KW - Endogenous Retroviruses/genetics

KW - Epistasis, Genetic

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Multiple Myeloma/genetics

KW - Polymorphism, Single Nucleotide

U2 - 10.1016/j.leukres.2015.06.014

DO - 10.1016/j.leukres.2015.06.014

M3 - Journal article

C2 - 26231931

SN - 0145-2126

VL - 39

SP - 1125

EP - 1128

JO - Leukemia Research

JF - Leukemia Research

IS - 10

ER -

Synergy of two human endogenous retroviruses in multiple myeloma

Abstract

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