Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock

Ayesha M Imam, Guang Jin, Michael Duggan, Martin Sillesen, John O Hwabejire, Cecilie H Jepsen, Danielle DePeralta, Baoling Liu, Jennifer Lu, Marc A deMoya, Simona Socrate, Hasan B Alam

40 Citationer (Scopus)

Abstract

Traumatic brain injury (TBI) and hemorrhagic shock (HS) are major causes of trauma-related deaths and are especially lethal as a combined insult. Previously, we showed that early administration of fresh frozen plasma (FFP) decreased the size of the brain lesion and associated swelling in a swine model of combined TBI+HS. We have also shown separately that addition of valproic acid (VPA) to the resuscitation protocol attenuates inflammatory markers in the brain as well as the degree of TBI. The current study was performed to determine whether a combined FFP+VPA treatment strategy would exert a synergistic effect.
OriginalsprogEngelsk
TidsskriftSurgery
Vol/bind154
Udgave nummer2
Sider (fra-til)388-96
Antal sider9
ISSN0039-6060
DOI
StatusUdgivet - aug. 2013

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