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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Synergistic antiviral effect in vitro of azidothymidine and amphotericin B methyl ester in combination on HIV infection.

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Vis graf over relationer
The nucleoside analogue azidothymidine (AZT) and the methyl ester of amphotericin B (AME) were assayed for antiviral effect on HIV infection singly and in combination. Both compounds were effective in inhibiting HIV infection of MT-4 cells. At concentrations where either compound alone had no significant effect on infection, the compounds in combination were potent inhibitors of HIV as evaluated by reduction in HIV antigen production and HIV induced cytopathic effect. These results indicate that a combination therapy employing compounds with different modes of action like AZT and AME may have synergistic antiviral properties. Amphotericin B itself significantly reduced HIV infectivity in vitro and should not be used as an antifungal agent in cultures intended to propagate HIV.
Bidragets oversatte titelSynergistic antiviral effect in vitro of azidothymidine and amphotericin B methyl ester in combination on HIV infection.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Infectious Diseases
Vol/bind24
Udgave nummer1
Sider (fra-til)35-39
Antal sider5
ISSN0036-5548
StatusUdgivet - 1992

ID: 32505885