@article{551e629d68cd4a9eb8d557737fc540b7,
title = "Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model",
abstract = "Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.",
keywords = "Animals, Anti-Bacterial Agents, Bacterial Load, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Female, Foreign Bodies, Histocytochemistry, Mice, Mice, Inbred BALB C, Peritonitis, Pseudomonas Infections, Pseudomonas aeruginosa, Quorum Sensing, Tobramycin",
author = "Louise Christensen and {van Gennip}, Maria and Jakobsen, {Tim Holm} and Morten Alhede and Hougen, {Hans Petter} and Niels H{\o}iby and Thomas Bjarnsholt and Givskov, {Michael Christian}",
year = "2012",
doi = "10.1093/jac/dks002",
language = "English",
volume = "67",
pages = "1198--206",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "5",
}