Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Sympathetic dysfunction of central origin in patients with ALS

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Early indicators of primary brain tumours: a population-based study with 10 years’ follow-up

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A European Academy of Neurology guideline on medical management issues in dementia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Deep phenotyping of facioscapulohumeral muscular dystrophy type 2 by magnetic resonance imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Characterization of Blood Pressure and Heart Rate Oscillations in POTS Patients via Uniform Phase Empirical Mode Decomposition

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Deep Brain Stimulation in Parkinson's Disease: Still Effective After More Than 8 Years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Amyotrophic lateral sclerosis (ALS) is a severe, progressive disease affecting both the central and peripheral parts of the motor nervous system. Some studies have shown unequivocal indications of a more disseminated disease also affecting the autonomic nervous system. We therefore evaluated the centrally and peripherally mediated autonomic vascular reflexes by (i) the local 133-Xenon washout technique, and (ii) the head-up tilt table test. The results correlated to clinical scores. We examined nine ALS patients and 15 age-matched controls. The 133-Xenon washout test showed a significant reduction in the centrally mediated sympathetic vasoconstrictor response, but a preserved locally mediated response in the patients. In the head-up tilt table test, the patients had a significantly higher mean arterial blood pressure (MAP) compared with controls, probably due to a general increase in vascular resistance. There were no correlations between the ALS Severity Scores and blood flow changes, diastolic blood pressure or MAP. Our study supports previous results, but indicates abnormalities consistent with a solely centrally located sympathetic dysfunction in ALS, independent of the stage of the disease.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Neurology
Vol/bind10
Udgave nummer3
Sider (fra-til)229-34
Antal sider6
ISSN1351-5101
StatusUdgivet - 1 maj 2003

ID: 32350576