Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Survival in Women Diagnosed With Breast Cancer During Pregnancy

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{dac2f58a0e644b1ba87ff9dec3ddf16c,
title = "Survival in Women Diagnosed With Breast Cancer During Pregnancy",
abstract = "INTRODUCTION: Pregnancy rarely coincides with breast cancer, but when it does, uncertainties remain about how survival is affected. In a nation-wide study, we investigated survival in women diagnosed with breast cancer during pregnancy.MATERIALS AND METHODS: Through health registries, we identified women with breast cancer at ages 15-44 years from 1973-2016 in Denmark and included 156 who were pregnant at diagnosis and 11,110 who were not. We compared overall mortality in pregnant and non-pregnant women using multivariate Cox regression stratified by time since cancer: <2 and ≥2 years.RESULTS: During the first 2 years after diagnosis, the hazard ratio of overall death was 2.28 (95% CI: 1.48-3.52) for pregnant versus non-pregnant breast cancer patients after adjustment for age and calendar period and 1.62 (95% CI: 1.05-2.50) after further adjustment for extent of disease. Adjusting for additional tumor characteristics, the hazard ratio was still significantly increased. Beyond the first 2 years, there was no excess mortality.CONCLUSION: Our study identifies the early period after breast cancer as a period of particular interest in future studies on survival after breast cancer in pregnancy. We found no evidence that survival is affected by pregnancy when 2 or more years have passed since diagnosis.",
author = "Viuff, {Jakob H} and Greiber, {Iben K} and Karlsen, {Mona Aa} and Lone Storgaard and Niels Kroman and Maj-Britt Jensen and Simone Eibye and Hjortsh{\o}j, {Cristel S} and Bent Ejlertsen and Winther, {Jeanette F} and Kj{\ae}r, {Susanne K} and Lene Mellemkj{\ae}r",
note = "Copyright {\textcopyright} 2021 Elsevier Inc. All rights reserved.",
year = "2022",
month = jun,
doi = "10.1016/j.clbc.2021.11.009",
language = "English",
volume = "22",
pages = "e517--e525",
journal = "Clinical breast cancer",
issn = "1526-8209",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Survival in Women Diagnosed With Breast Cancer During Pregnancy

AU - Viuff, Jakob H

AU - Greiber, Iben K

AU - Karlsen, Mona Aa

AU - Storgaard, Lone

AU - Kroman, Niels

AU - Jensen, Maj-Britt

AU - Eibye, Simone

AU - Hjortshøj, Cristel S

AU - Ejlertsen, Bent

AU - Winther, Jeanette F

AU - Kjær, Susanne K

AU - Mellemkjær, Lene

N1 - Copyright © 2021 Elsevier Inc. All rights reserved.

PY - 2022/6

Y1 - 2022/6

N2 - INTRODUCTION: Pregnancy rarely coincides with breast cancer, but when it does, uncertainties remain about how survival is affected. In a nation-wide study, we investigated survival in women diagnosed with breast cancer during pregnancy.MATERIALS AND METHODS: Through health registries, we identified women with breast cancer at ages 15-44 years from 1973-2016 in Denmark and included 156 who were pregnant at diagnosis and 11,110 who were not. We compared overall mortality in pregnant and non-pregnant women using multivariate Cox regression stratified by time since cancer: <2 and ≥2 years.RESULTS: During the first 2 years after diagnosis, the hazard ratio of overall death was 2.28 (95% CI: 1.48-3.52) for pregnant versus non-pregnant breast cancer patients after adjustment for age and calendar period and 1.62 (95% CI: 1.05-2.50) after further adjustment for extent of disease. Adjusting for additional tumor characteristics, the hazard ratio was still significantly increased. Beyond the first 2 years, there was no excess mortality.CONCLUSION: Our study identifies the early period after breast cancer as a period of particular interest in future studies on survival after breast cancer in pregnancy. We found no evidence that survival is affected by pregnancy when 2 or more years have passed since diagnosis.

AB - INTRODUCTION: Pregnancy rarely coincides with breast cancer, but when it does, uncertainties remain about how survival is affected. In a nation-wide study, we investigated survival in women diagnosed with breast cancer during pregnancy.MATERIALS AND METHODS: Through health registries, we identified women with breast cancer at ages 15-44 years from 1973-2016 in Denmark and included 156 who were pregnant at diagnosis and 11,110 who were not. We compared overall mortality in pregnant and non-pregnant women using multivariate Cox regression stratified by time since cancer: <2 and ≥2 years.RESULTS: During the first 2 years after diagnosis, the hazard ratio of overall death was 2.28 (95% CI: 1.48-3.52) for pregnant versus non-pregnant breast cancer patients after adjustment for age and calendar period and 1.62 (95% CI: 1.05-2.50) after further adjustment for extent of disease. Adjusting for additional tumor characteristics, the hazard ratio was still significantly increased. Beyond the first 2 years, there was no excess mortality.CONCLUSION: Our study identifies the early period after breast cancer as a period of particular interest in future studies on survival after breast cancer in pregnancy. We found no evidence that survival is affected by pregnancy when 2 or more years have passed since diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=85121831922&partnerID=8YFLogxK

U2 - 10.1016/j.clbc.2021.11.009

DO - 10.1016/j.clbc.2021.11.009

M3 - Journal article

C2 - 34963614

VL - 22

SP - e517-e525

JO - Clinical breast cancer

JF - Clinical breast cancer

SN - 1526-8209

IS - 4

ER -

ID: 73863926