Survival in Women Diagnosed With Breast Cancer During Pregnancy

Jakob H Viuff, Iben K Greiber, Mona Aa Karlsen, Lone Storgaard, Niels Kroman, Maj-Britt Jensen, Simone Eibye, Cristel S Hjortshøj, Bent Ejlertsen, Jeanette F Winther, Susanne K Kjær, Lene Mellemkjær

3 Citationer (Scopus)

Abstract

INTRODUCTION: Pregnancy rarely coincides with breast cancer, but when it does, uncertainties remain about how survival is affected. In a nation-wide study, we investigated survival in women diagnosed with breast cancer during pregnancy.

MATERIALS AND METHODS: Through health registries, we identified women with breast cancer at ages 15-44 years from 1973-2016 in Denmark and included 156 who were pregnant at diagnosis and 11,110 who were not. We compared overall mortality in pregnant and non-pregnant women using multivariate Cox regression stratified by time since cancer: <2 and ≥2 years.

RESULTS: During the first 2 years after diagnosis, the hazard ratio of overall death was 2.28 (95% CI: 1.48-3.52) for pregnant versus non-pregnant breast cancer patients after adjustment for age and calendar period and 1.62 (95% CI: 1.05-2.50) after further adjustment for extent of disease. Adjusting for additional tumor characteristics, the hazard ratio was still significantly increased. Beyond the first 2 years, there was no excess mortality.

CONCLUSION: Our study identifies the early period after breast cancer as a period of particular interest in future studies on survival after breast cancer in pregnancy. We found no evidence that survival is affected by pregnancy when 2 or more years have passed since diagnosis.

OriginalsprogEngelsk
TidsskriftClinical breast cancer
Vol/bind22
Udgave nummer4
Sider (fra-til)e517-e525
ISSN1526-8209
DOI
StatusUdgivet - jun. 2022

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