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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Survival after Out-of-Hospital Cardiac Arrest in Relation to Sex: A Nationwide Registry-based Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AIM: Crude survival has increased following an out-of-hospital cardiac arrest (OHCA). We aimed to study sex-related differences in patient characteristics and survival during a 10-year study period.

METHODS: Patients ≥12 years old with OHCA of a presumed cardiac cause, and in whom resuscitation was attempted, were identified through the Danish Cardiac Arrest Registry 20012010. A total of 19,372 patients were included.

RESULTS: One-third were female, with a median age of 75 years (IQR 65-83). Compared to females, males were five years younger; and less likely to have severe comorbidities e.g. chronic obstructive pulmonary disease (12.8% vs. 16.5%); but more likely to have arrest outside of the home (29.4% vs. 18.7%), receive bystander CPR (32.9% vs. 25.9%), and have a shockable rhythm (32.6% vs. 17.2%), all p<0.001. Thirty-day crude survival increased in males (3.0% in 2001 to 12.9% in 2010); and in females (4.8% in 2001 to 6.7% in 2010), p<0.001. Multivariable logistic regression analyses adjusted for patient characteristics including comorbidities, showed no survival difference between sexes in patients with a non-shockable rhythm (OR1.00;CI0.72-1.40), while female sex was positively associated with survival in patients with a shockable rhythm (OR1.31;CI1.07-1.59). Analyses were rhythm-stratified due to interaction between sex and heart rhythm. There was no interaction between sex and calendar-year.

CONCLUSIONS: Temporal increase in crude survival was more marked in males due to poorer prognostic characteristics in females with a lower proportion of shockable rhythm. In an adjusted model, female sex was positively associated with survival in patients with a shockable rhythm.

OriginalsprogEngelsk
TidsskriftResuscitation
Vol/bind85
Udgave nummer9
Sider (fra-til)1212-1218
ISSN0300-9572
DOI
StatusUdgivet - 21 jun. 2014

ID: 44372141