TY - JOUR
T1 - Surgical treatment of 61 consecutive patients with maxillary stage 3 medication-related osteonecrosis of the jaws using a pedicled buccal fat pad
AU - Andersen, Sanne Werner Moeller
AU - Mogensen, Ditte Gertz
AU - Schioedt, Morten
AU - Kofod, Thomas
N1 - © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/6
Y1 - 2023/6
N2 - PURPOSE: Buccal fat pad (BFP) is used for the closure of large oroantral defects caused by surgical removal of the necrotic bone in patients with medication-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the use of BFP for the closure of maxillary sinus defects in stage 3 MRONJ patients.METHODS: This study recruited 61patients with large oroantral defects caused by MRONJ, including 49 patients with cancer and 12 patients with osteoporosis. Lesions were evaluated clinically and radiographically.RESULTS: Among the 61 patients, 51 (83.6%) healed uneventfully, and 5 patients (8.2%) had local dehiscence and exposed bone; these 56 patients (91.8%) all healed after first or second operation. The Eastern Cooperative Oncology Group Performance Status was associated with being non-cured and might be an indicator for the healing process. All patients experienced a significant increase in body weight postoperatively.CONCLUSIONS: This study suggest that block resection with removal of the necrotic bone combined with radical sinusotomy and closure of the defect with BFP is a reliable method to cure MRONJ lesions with a high success rate, and successful operation and prosthetic rehabilitation may improve body weight and the quality of life. The study was approved by the appropriate ethical approval for the Copenhagen ONJ Cohort (protocol no. H-6-2013-010) November 20, 2013.
AB - PURPOSE: Buccal fat pad (BFP) is used for the closure of large oroantral defects caused by surgical removal of the necrotic bone in patients with medication-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the use of BFP for the closure of maxillary sinus defects in stage 3 MRONJ patients.METHODS: This study recruited 61patients with large oroantral defects caused by MRONJ, including 49 patients with cancer and 12 patients with osteoporosis. Lesions were evaluated clinically and radiographically.RESULTS: Among the 61 patients, 51 (83.6%) healed uneventfully, and 5 patients (8.2%) had local dehiscence and exposed bone; these 56 patients (91.8%) all healed after first or second operation. The Eastern Cooperative Oncology Group Performance Status was associated with being non-cured and might be an indicator for the healing process. All patients experienced a significant increase in body weight postoperatively.CONCLUSIONS: This study suggest that block resection with removal of the necrotic bone combined with radical sinusotomy and closure of the defect with BFP is a reliable method to cure MRONJ lesions with a high success rate, and successful operation and prosthetic rehabilitation may improve body weight and the quality of life. The study was approved by the appropriate ethical approval for the Copenhagen ONJ Cohort (protocol no. H-6-2013-010) November 20, 2013.
KW - Adipose Tissue/surgery
KW - Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnostic imaging
KW - Bone Density Conservation Agents
KW - Humans
KW - Maxilla
KW - Quality of Life
KW - Wound Healing
KW - Reconstruction
KW - MRONJ
KW - Buccal fat pad
KW - Quality of life
KW - Antiresorptive treatment
KW - Jaw osteonecrosis
UR - http://www.scopus.com/inward/record.url?scp=85127395829&partnerID=8YFLogxK
U2 - 10.1007/s10006-022-01061-2
DO - 10.1007/s10006-022-01061-2
M3 - Journal article
C2 - 35362853
SN - 1865-1550
VL - 27
SP - 251
EP - 261
JO - Oral and Maxillofacial Surgery
JF - Oral and Maxillofacial Surgery
IS - 2
ER -