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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Supplementation with fish oil in pregnancy reduces gastroenteritis in early childhood

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

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BACKGROUND: We hypothesised that insufficient intake of fish oil derived omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first three years of life.

METHODS: A double blinded, randomised controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until one week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis and the risk of having a gastroenteritis episode in the first three years of life.

RESULTS: A median reduction of 2.5 days with gastroenteritis (p=0.018), corresponding to a 14% reduction in the n-3 LCPUFA group compared with the controls in the first three years of life (p=0.037). A reduction in the number of gastroenteritis episodes (p=0.027) and reduced risk of having an episode (HR 0.80 [0.66-0.97], p=0.023).

CONCLUSION: Fish oil supplementation from the 24 th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first three years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.

OriginalsprogEngelsk
TidsskriftThe Journal of infectious diseases
ISSN0022-1899
DOI
StatusE-pub ahead of print - 20 dec. 2021

Bibliografisk note

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

ID: 74541665