TY - JOUR
T1 - Suicidal Ideation and Non-Suicidal Self-Injury Following Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 11
AU - Gregersen, Maja
AU - Jepsen, Jens Richardt Møllegaard
AU - Brandt, Julie Marie
AU - Søndergaard, Anne
AU - Rohd, Sinnika Birkehøj
AU - Veddum, Lotte
AU - Knudsen, Christina Bruun
AU - Andreassen, Anna Krogh
AU - Burton, Birgitte Klee
AU - Hjorthøj, Carsten
AU - Krantz, Mette Falkenberg
AU - Greve, Aja Neergaard
AU - Bliksted, Vibeke
AU - Mors, Ole
AU - Nordentoft, Merete
AU - Thorup, Anne Amalie Elgaard
AU - Hemager, Nicoline
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: [email protected].
PY - 2023/11/29
Y1 - 2023/11/29
N2 - BACKGROUND AND HYPOTHESIS: Suicide is a leading cause of death in youth and is often preceded by suicidal ideation (SI) and non-suicidal self-injury (NSSI). Identifying early markers of risk for SI and NSSI could improve timely identification of at-risk individuals.STUDY DESIGN: Children (mean age 11.9, SD 0.2) at familial high risk of schizophrenia (N = 171), or bipolar disorder (N = 104), and controls (N = 174) were assessed for psychotic experiences (PE), SI, NSSI, and Axis I mental disorders in face-to-face interviews in early and middle childhood (age 7 and 11).STUDY RESULTS: Having 2 types of early childhood PE predicted middle childhood SI after accounting for previous SI, NSSI, and mental disorders (OR 2.8, 95% CI 1.1-6.9; P = .03). Two PE predicted NSSI (OR 3.0, 95% CI 1.2-7.7; P = .02) in excess of previous SI, NSSI, mental disorders, and familial risk. Persistent and incident PE predicted SI (OR 3.2, 95% CI, 1.1-8.8; P = .03; OR 3.8, 95% CI, 1.3-11.5; P = .02) in the fully adjusted model. Nineteen percent of children with persistent PE reported middle childhood SI vs 3.8% of those who never reported PE. In children with early childhood mental disorders, those who reported 2 PE had 4.4-fold increased odds of later SI (95% CI, 1.2-16.7; P = .03) after adjustments. PE were nondifferentially associated with outcomes across familial risk groups.CONCLUSIONS: Early childhood PE index elevated risk for subsequent SI and NSSI beyond what can be attributed to presence of mental disorders. Mental health screenings and clinical assessments should include early childhood PE.
AB - BACKGROUND AND HYPOTHESIS: Suicide is a leading cause of death in youth and is often preceded by suicidal ideation (SI) and non-suicidal self-injury (NSSI). Identifying early markers of risk for SI and NSSI could improve timely identification of at-risk individuals.STUDY DESIGN: Children (mean age 11.9, SD 0.2) at familial high risk of schizophrenia (N = 171), or bipolar disorder (N = 104), and controls (N = 174) were assessed for psychotic experiences (PE), SI, NSSI, and Axis I mental disorders in face-to-face interviews in early and middle childhood (age 7 and 11).STUDY RESULTS: Having 2 types of early childhood PE predicted middle childhood SI after accounting for previous SI, NSSI, and mental disorders (OR 2.8, 95% CI 1.1-6.9; P = .03). Two PE predicted NSSI (OR 3.0, 95% CI 1.2-7.7; P = .02) in excess of previous SI, NSSI, mental disorders, and familial risk. Persistent and incident PE predicted SI (OR 3.2, 95% CI, 1.1-8.8; P = .03; OR 3.8, 95% CI, 1.3-11.5; P = .02) in the fully adjusted model. Nineteen percent of children with persistent PE reported middle childhood SI vs 3.8% of those who never reported PE. In children with early childhood mental disorders, those who reported 2 PE had 4.4-fold increased odds of later SI (95% CI, 1.2-16.7; P = .03) after adjustments. PE were nondifferentially associated with outcomes across familial risk groups.CONCLUSIONS: Early childhood PE index elevated risk for subsequent SI and NSSI beyond what can be attributed to presence of mental disorders. Mental health screenings and clinical assessments should include early childhood PE.
KW - Adolescent
KW - Bipolar Disorder/epidemiology
KW - Child
KW - Child, Preschool
KW - Denmark/epidemiology
KW - Genetic Predisposition to Disease
KW - Humans
KW - Mental Disorders
KW - Risk Factors
KW - Schizophrenia/epidemiology
KW - Self-Injurious Behavior/epidemiology
KW - Suicidal Ideation
KW - Suicide, Attempted
UR - http://www.scopus.com/inward/record.url?scp=85178498810&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbad052
DO - 10.1093/schbul/sbad052
M3 - Journal article
C2 - 37171862
SN - 0586-7614
VL - 49
SP - 1602
EP - 1613
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 6
ER -