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Region Hovedstaden - en del af Københavns Universitetshospital
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Successful Treatment of Rhino-Orbital-Cerebral Mucormycosis in a Child With Leukemia

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Vis graf over relationer

Rhino-orbital-cerebral mucormycosis (ROCM) is a rare fulminant opportunistic fungal infection that despite relevant treatment has high mortality. We present a case of a 3-year-old girl with acute lymphoblastic leukemia and ROCM, who was treated successfully with excessive surgery, systemic antifungal treatment with amphotericin B (AmB), posaconazole, and terbinafine as well as hyperbaric oxygen. Surgery included, beside extracranial and intracranial removal of infected areas, endoscopic sinus and skull base surgery with local AmB installation and in addition placement of an Ommaya reservoir for 114 intrathecal administrations of AmB. In addition, we review the literature of ROCM in pediatric patients with hematological diseases.

OriginalsprogEngelsk
TidsskriftJournal of Pediatric Hematology / Oncology
Vol/bind39
Udgave nummer4
Sider (fra-til)e211-e215
ISSN1077-4114
DOI
StatusUdgivet - 2017

ID: 49632427