TY - JOUR
T1 - Successful Treatment of Rhino-Orbital-Cerebral Mucormycosis in a Child With Leukemia
AU - Jensen, Thorbjørn Søren Rønn
AU - Arendrup, Maiken Cavling
AU - Buchwald, Christian von
AU - Frandsen, Thomas L
AU - Juhler, Marianne
AU - Nygaard, Ulrikka
PY - 2017
Y1 - 2017
N2 - Rhino-orbital-cerebral mucormycosis (ROCM) is a rare fulminant opportunistic fungal infection that despite relevant treatment has high mortality. We present a case of a 3-year-old girl with acute lymphoblastic leukemia and ROCM, who was treated successfully with excessive surgery, systemic antifungal treatment with amphotericin B (AmB), posaconazole, and terbinafine as well as hyperbaric oxygen. Surgery included, beside extracranial and intracranial removal of infected areas, endoscopic sinus and skull base surgery with local AmB installation and in addition placement of an Ommaya reservoir for 114 intrathecal administrations of AmB. In addition, we review the literature of ROCM in pediatric patients with hematological diseases.
AB - Rhino-orbital-cerebral mucormycosis (ROCM) is a rare fulminant opportunistic fungal infection that despite relevant treatment has high mortality. We present a case of a 3-year-old girl with acute lymphoblastic leukemia and ROCM, who was treated successfully with excessive surgery, systemic antifungal treatment with amphotericin B (AmB), posaconazole, and terbinafine as well as hyperbaric oxygen. Surgery included, beside extracranial and intracranial removal of infected areas, endoscopic sinus and skull base surgery with local AmB installation and in addition placement of an Ommaya reservoir for 114 intrathecal administrations of AmB. In addition, we review the literature of ROCM in pediatric patients with hematological diseases.
U2 - 10.1097/MPH.0000000000000701
DO - 10.1097/MPH.0000000000000701
M3 - Journal article
C2 - 27841827
SN - 1077-4114
VL - 39
SP - e211-e215
JO - Journal of Pediatric Hematology / Oncology
JF - Journal of Pediatric Hematology / Oncology
IS - 4
ER -