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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Substantial Lymphovascular Space Invasion Is an Adverse Prognostic Factor in High-risk Endometrial Cancer

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  1. Defining Substantial Lymphovascular Space Invasion in Endometrial Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. A Selective Biomarker Panel Increases the Reproducibility and the Accuracy in Endometrial Biopsy Diagnosis

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  4. Glycogen Storage Disease Type IV: A Case With Histopathologic Findings in First-Trimester Placental Tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. History of gynecological pathology XXV. Dr Gunnar Teilum

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Preoperative predictors of inguinal lymph node metastases in vulvar cancer - A nationwide study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Defining Substantial Lymphovascular Space Invasion in Endometrial Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Identification of Stably Expressed Reference microRNAs in Epithelial Ovarian Cancer

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  4. CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis

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  5. MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma

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Vis graf over relationer

Approximately 15% of patients with endometrial cancer present with high-risk disease (HREC). Moreover, assessing the extent of lymphovascular space invasion (LVSI) may provide prognostic insight among patients with HREC. The aim of this study was to determine whether the extent of LVSI can serve as a prognostic factor in HREC. All cases of ESMO-ESGO-ESTRO 2016 classified HREC in the Danish Gynecological Cancer Database (DGCD) diagnosed from 2005 to 2012 were reviewed for the presence and extent of LVSI (categorized using a 3-tiered definition). We used the Kaplan-Meier analysis to calculate actuarial survival rates, both adjusted and unadjusted Cox regression analyses were used to calculate the proportional hazard ratio (HR). A total of 376 patients were included in our analysis. Among 305 patients with stage I/II HREC, 8.2% and 6.2% had focal or substantial LVSI, respectively, compared with 12.7% and 38.0% of 71 patients with stage III/IV HREC, respectively. Moreover, the estimated 5-yr recurrence-free survival rate was significantly lower among patients with substantial LVSI compared with patients with no LVSI for both stage I/II (HR: 2.8; P=0.011) and stage III/IV (HR: 2.9; P=0.003) patients. Similarly, overall survival was significantly lower among patients with substantial LVSI for both stage I/II (HR: 3.1; P<0.001) and stage III/IV (HR: 3.2; P=0.020) patients. In patients with HREC, substantial LVSI is an independent adverse prognostic factor for lymph node and distant metastases, leading to reduced survival. Thus, the extent of LVSI should be incorporated into routine pathology reports in order to guide the appropriate choice of adjuvant treatment.

OriginalsprogEngelsk
TidsskriftInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Vol/bind41
Udgave nummer3
Sider (fra-til)227-234
Antal sider8
ISSN0277-1691
DOI
StatusUdgivet - 1 maj 2022

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Copyright ©2021International Society of Gynecological Pathologists.

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