- Hospitaler/Afdelinger Se de enkelte afdelingers forskningsprofil
- Forskere Søg forskere og deres videnskabelige arbejde
- Publikationer Publikationer med forskere fra Region Hovedstaden
- Forskningsprojekter Søg projekter/clinical trials i Region Hovedstaden
- Aktiviteter Med forskere fra Region Hovedstaden
Forskning
Udskriv
Switch language
Region Hovedstaden
- en del af Københavns Universitetshospital
Udgivet
Subsequent Event Risk in Individuals With Established Coronary Heart Disease
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Harvard
Patel, RS, Tragante, V, Schmidt, AF, McCubrey, RO, Holmes, MV, Howe, LJ, Direk, K, Åkerblom, A, Leander, K, Virani, SS, Kaminski, KA, Muehlschlegel, JD, Allayee, H, Almgren, P, Alver, M, Baranova, EV, Behloui, H, Boeckx, B, Braund, PS, Breitling, LP, Delgado, G, Duarte, NE, Dubé, M-P, Dufresne, L, Eriksson, N, Foco, L, Scholz, M, Gijsberts, CM, Glinge, C, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, JA, Kleber, M, Kofink, D, Kotti, S, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, PA, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, CP, Nikus, K, Pilbrow, AP, Ploski, R, Sun, YV, Tanck, MWT, Tang, WHW, Trompet, S, van der Laan, SW, Van Setten, J, Vilmundarson, RO, Viviani Anselmi, C, Vlachopoulou, E, Al Ali, L, Boerwinkle, E, Briguori, C, Carlquist, JF, Carruthers, KF, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Engstrøm, T, Fitzpatrick, N, Fox, K, Gigante, B, James, S, Lokki, M-L, Lotufo, PA, Marziliano, N, Mordi, IR, Muhlestein, JB, Newton-Cheh, C, Pitha, J, Saely, CH, Samman-Tahhan, A, Sandesara, PB, Teren, A, Timmis, A, Van de Werf, F, Wauters, E, Wilde, AAM, Ford, I, Stott, DJ, Algra, A, Andreassi, MG, Ardissino, D, Arsenault, BJ, Ballantyne, CM, Bergmeijer, TO, Bezzina, CR, Body, SC, Boersma, EH, Bogaty, P, Bots, ML, Brenner, H, Brugts, JJ, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-DeHoff, RM, Cresci, S, Danchin, N, de Faire, U, Doughty, RN, Drexel, H, Engert, JC, Fox, KAA, Girelli, D, Grobbee, DE, Hagström, E, Hazen, SL, Held, C, Hemingway, H, Hoefer, IE, Hovingh, GK, Jabbari, R, Johnson, JA, Jukema, JW, Kaczor, MP, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, OH, Lagerqvist, B, Lambrechts, D, Laurikka, JO, Lehtimäki, T, Lindholm, D, Mahmoodi, BK, Maitland-van der Zee, AH, McPherson, R, Melander, O, Metspalu, A, Niemcunowicz-Janica, A, Olivieri, O, Opolski, G, Palmer, CN, Pasterkamp, G, Pepine, CJ, Pereira, AC, Pilote, L, Quyyumi, AA, Richards, AM, Sanak, M, Siegbahn, A, Simon, T, Sinisalo, J, Smith, JG, Spertus, JA, Stender, S, Stewart, AFR, Szczeklik, W, Szpakowicz, A, Tardif, J-C, Ten Berg, JM, Tfelt-Hansen, J, Thanassoulis, G, Thiery, J, Torp-Pedersen, C, van der Graaf, Y, Visseren, FLJ, Waltenberger, J, Weeke, PE, Van der Harst, P, Lang, CC, Sattar, N, Cameron, VA, Anderson, JL, Brophy, JM, Pare, G, Horne, BD, März, W, Wallentin, L, Samani, NJ, Hingorani, AD & Asselbergs, FW 2019, 'Subsequent Event Risk in Individuals With Established Coronary Heart Disease' Circulation. Genomic and precision medicine, bind 12, nr. 4, s. e002470. https://doi.org/10.1161/CIRCGEN.119.002470
APA
Patel, R. S., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., ... Asselbergs, F. W. (2019). Subsequent Event Risk in Individuals With Established Coronary Heart Disease. Circulation. Genomic and precision medicine, 12(4), e002470. https://doi.org/10.1161/CIRCGEN.119.002470
CBE
Patel RS, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Allayee H, Almgren P, Alver M, Baranova EV, Behloui H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dubé M-P, Dufresne L, Eriksson N, Foco L, Scholz M, Gijsberts CM, Glinge C, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kotti S, Kuukasjärvi P, Lee V-V, Leiherer A, Lenzini PA, Levin D, Lyytikäinen L-P, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, Van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Al Ali L, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Engstrøm T, Fitzpatrick N, Fox K, Gigante B, James S, Lokki M-L, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton-Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timmis A, Van de Werf F, Wauters E, Wilde AAM, Ford I, Stott DJ, Algra A, Andreassi MG, Ardissino D, Arsenault BJ, Ballantyne CM, Bergmeijer TO, Bezzina CR, Body SC, Boersma EH, Bogaty P, Bots ML, Brenner H, Brugts JJ, Burkhardt R, Carpeggiani C, Condorelli G, Cooper-DeHoff RM, Cresci S, Danchin N, de Faire U, Doughty RN, Drexel H, Engert JC, Fox KAA, Girelli D, Grobbee DE, Hagström E, Hazen SL, Held C, Hemingway H, Hoefer IE, Hovingh GK, Jabbari R, Johnson JA, Jukema JW, Kaczor MP, Kähönen M, Kettner J, Kiliszek M, Klungel OH, Lagerqvist B, Lambrechts D, Laurikka JO, Lehtimäki T, Lindholm D, Mahmoodi BK, Maitland-van der Zee AH, McPherson R, Melander O, Metspalu A, Niemcunowicz-Janica A, Olivieri O, Opolski G, Palmer CN, Pasterkamp G, Pepine CJ, Pereira AC, Pilote L, Quyyumi AA, Richards AM, Sanak M, Siegbahn A, Simon T, Sinisalo J, Smith JG, Spertus JA, Stender S, Stewart AFR, Szczeklik W, Szpakowicz A, Tardif J-C, Ten Berg JM, Tfelt-Hansen J, Thanassoulis G, Thiery J, Torp-Pedersen C, van der Graaf Y, Visseren FLJ, Waltenberger J, Weeke PE, Van der Harst P, Lang CC, Sattar N, Cameron VA, Anderson JL, Brophy JM, Pare G, Horne BD, März W, Wallentin L, Samani NJ, Hingorani AD, Asselbergs FW. 2019. Subsequent Event Risk in Individuals With Established Coronary Heart Disease. Circulation. Genomic and precision medicine. 12(4):e002470. https://doi.org/10.1161/CIRCGEN.119.002470
MLA
Patel, Riyaz S o.a.. "Subsequent Event Risk in Individuals With Established Coronary Heart Disease". Circulation. Genomic and precision medicine. 2019, 12(4). e002470. https://doi.org/10.1161/CIRCGEN.119.002470
Vancouver
Patel RS, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ o.a. Subsequent Event Risk in Individuals With Established Coronary Heart Disease. Circulation. Genomic and precision medicine. 2019 apr;12(4):e002470. https://doi.org/10.1161/CIRCGEN.119.002470
Author
Bibtex
@article{bdd8a18b18c1475492c1e39de5e903fd,
title = "Subsequent Event Risk in Individuals With Established Coronary Heart Disease",
abstract = "BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38{\%}-100{\%}), mostly male (44{\%}-91{\%}) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95{\%} CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95{\%} CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95{\%} CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.",
author = "Patel, {Riyaz S} and Vinicius Tragante and Schmidt, {Amand F} and McCubrey, {Raymond O} and Holmes, {Michael V} and Howe, {Laurence J} and Kenan Direk and Axel {\AA}kerblom and Karin Leander and Virani, {Salim S} and Kaminski, {Karol A} and Muehlschlegel, {Jochen D} and Hooman Allayee and Peter Almgren and Maris Alver and Baranova, {Ekaterina V} and Hassan Behloui and Bram Boeckx and Braund, {Peter S} and Breitling, {Lutz P} and Graciela Delgado and Duarte, {Nubia E} and Marie-Pierre Dub{\'e} and Line Dufresne and Niclas Eriksson and Luisa Foco and Markus Scholz and Gijsberts, {Crystel M} and Charlotte Glinge and Yan Gong and Jaana Hartiala and Mahyar Heydarpour and Hubacek, {Jaroslav A} and Marcus Kleber and Daniel Kofink and Salma Kotti and Pekka Kuukasj{\"a}rvi and Vei-Vei Lee and Andreas Leiherer and Lenzini, {Petra A} and Daniel Levin and Leo-Pekka Lyytik{\"a}inen and Nicola Martinelli and Ute Mons and Nelson, {Christopher P} and Kjell Nikus and Pilbrow, {Anna P} and Rafal Ploski and Sun, {Yan V} and Tanck, {Michael W T} and Tang, {W H Wilson} and Stella Trompet and {van der Laan}, {Sander W} and {Van Setten}, Jessica and Vilmundarson, {Ragnar O} and {Viviani Anselmi}, Chiara and Efthymia Vlachopoulou and {Al Ali}, Lawien and Eric Boerwinkle and Carlo Briguori and Carlquist, {John F} and Carruthers, {Kathryn F} and Gavino Casu and John Deanfield and Panos Deloukas and Frank Dudbridge and Thomas Engstr{\o}m and Natalie Fitzpatrick and Kim Fox and Bruna Gigante and Stefan James and Marja-Liisa Lokki and Lotufo, {Paulo A} and Nicola Marziliano and Mordi, {Ify R} and Muhlestein, {Joseph B} and Christopher Newton-Cheh and Jan Pitha and Saely, {Christoph H} and Ayman Samman-Tahhan and Sandesara, {Pratik B} and Andrej Teren and Adam Timmis and {Van de Werf}, Frans and Els Wauters and Wilde, {Arthur A M} and Ian Ford and Stott, {David J} and Ale Algra and Andreassi, {Maria G} and Diego Ardissino and Arsenault, {Benoit J} and Ballantyne, {Christie M} and Bergmeijer, {Thomas O} and Bezzina, {Connie R} and Body, {Simon C} and Boersma, {Eric H} and Peter Bogaty and Bots, {Michiel L} and Hermann Brenner and Brugts, {Jasper J} and Ralph Burkhardt and Clara Carpeggiani and Gianluigi Condorelli and Cooper-DeHoff, {Rhonda M} and Sharon Cresci and Nicolas Danchin and {de Faire}, Ulf and Doughty, {Robert N} and Heinz Drexel and Engert, {James C} and Fox, {Keith A A} and Domenico Girelli and Grobbee, {Diederick E} and Emil Hagstr{\"o}m and Hazen, {Stanley L} and Claes Held and Harry Hemingway and Hoefer, {Imo E} and Hovingh, {G Kees} and Reza Jabbari and Johnson, {Julie A} and Jukema, {J Wouter} and Kaczor, {Marcin P} and Mika K{\"a}h{\"o}nen and Jiri Kettner and Marek Kiliszek and Klungel, {Olaf H} and Bo Lagerqvist and Diether Lambrechts and Laurikka, {Jari O} and Terho Lehtim{\"a}ki and Daniel Lindholm and Mahmoodi, {B K} and {Maitland-van der Zee}, {Anke H} and Ruth McPherson and Olle Melander and Andres Metspalu and Anna Niemcunowicz-Janica and Oliviero Olivieri and Grzegorz Opolski and Palmer, {Colin N} and Gerard Pasterkamp and Pepine, {Carl J} and Pereira, {Alexandre C} and Louise Pilote and Quyyumi, {Arshed A} and Richards, {A Mark} and Marek Sanak and Agneta Siegbahn and Tabassome Simon and Juha Sinisalo and Smith, {J Gustav} and Spertus, {John A} and Steen Stender and Stewart, {Alexandre F R} and Wojciech Szczeklik and Anna Szpakowicz and Jean-Claude Tardif and {Ten Berg}, {Jurri{\"e}n M} and Jacob Tfelt-Hansen and George Thanassoulis and Joachim Thiery and Christian Torp-Pedersen and {van der Graaf}, Yolanda and Visseren, {Frank L J} and Johannes Waltenberger and Weeke, {Peter E} and {Van der Harst}, Pim and Lang, {Chim C} and Naveed Sattar and Cameron, {Vicky A} and Anderson, {Jeffrey L} and Brophy, {James M} and Guillaume Pare and Horne, {Benjamin D} and Winfried M{\"a}rz and Lars Wallentin and Samani, {Nilesh J} and Hingorani, {Aroon D} and Asselbergs, {Folkert W}",
year = "2019",
month = "4",
doi = "10.1161/CIRCGEN.119.002470",
language = "English",
volume = "12",
pages = "e002470",
journal = "Circulation. Genomic and precision medicine",
issn = "2574-8300",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "4",
}
RIS
TY - JOUR
T1 - Subsequent Event Risk in Individuals With Established Coronary Heart Disease
AU - Patel, Riyaz S
AU - Tragante, Vinicius
AU - Schmidt, Amand F
AU - McCubrey, Raymond O
AU - Holmes, Michael V
AU - Howe, Laurence J
AU - Direk, Kenan
AU - Åkerblom, Axel
AU - Leander, Karin
AU - Virani, Salim S
AU - Kaminski, Karol A
AU - Muehlschlegel, Jochen D
AU - Allayee, Hooman
AU - Almgren, Peter
AU - Alver, Maris
AU - Baranova, Ekaterina V
AU - Behloui, Hassan
AU - Boeckx, Bram
AU - Braund, Peter S
AU - Breitling, Lutz P
AU - Delgado, Graciela
AU - Duarte, Nubia E
AU - Dubé, Marie-Pierre
AU - Dufresne, Line
AU - Eriksson, Niclas
AU - Foco, Luisa
AU - Scholz, Markus
AU - Gijsberts, Crystel M
AU - Glinge, Charlotte
AU - Gong, Yan
AU - Hartiala, Jaana
AU - Heydarpour, Mahyar
AU - Hubacek, Jaroslav A
AU - Kleber, Marcus
AU - Kofink, Daniel
AU - Kotti, Salma
AU - Kuukasjärvi, Pekka
AU - Lee, Vei-Vei
AU - Leiherer, Andreas
AU - Lenzini, Petra A
AU - Levin, Daniel
AU - Lyytikäinen, Leo-Pekka
AU - Martinelli, Nicola
AU - Mons, Ute
AU - Nelson, Christopher P
AU - Nikus, Kjell
AU - Pilbrow, Anna P
AU - Ploski, Rafal
AU - Sun, Yan V
AU - Tanck, Michael W T
AU - Tang, W H Wilson
AU - Trompet, Stella
AU - van der Laan, Sander W
AU - Van Setten, Jessica
AU - Vilmundarson, Ragnar O
AU - Viviani Anselmi, Chiara
AU - Vlachopoulou, Efthymia
AU - Al Ali, Lawien
AU - Boerwinkle, Eric
AU - Briguori, Carlo
AU - Carlquist, John F
AU - Carruthers, Kathryn F
AU - Casu, Gavino
AU - Deanfield, John
AU - Deloukas, Panos
AU - Dudbridge, Frank
AU - Engstrøm, Thomas
AU - Fitzpatrick, Natalie
AU - Fox, Kim
AU - Gigante, Bruna
AU - James, Stefan
AU - Lokki, Marja-Liisa
AU - Lotufo, Paulo A
AU - Marziliano, Nicola
AU - Mordi, Ify R
AU - Muhlestein, Joseph B
AU - Newton-Cheh, Christopher
AU - Pitha, Jan
AU - Saely, Christoph H
AU - Samman-Tahhan, Ayman
AU - Sandesara, Pratik B
AU - Teren, Andrej
AU - Timmis, Adam
AU - Van de Werf, Frans
AU - Wauters, Els
AU - Wilde, Arthur A M
AU - Ford, Ian
AU - Stott, David J
AU - Algra, Ale
AU - Andreassi, Maria G
AU - Ardissino, Diego
AU - Arsenault, Benoit J
AU - Ballantyne, Christie M
AU - Bergmeijer, Thomas O
AU - Bezzina, Connie R
AU - Body, Simon C
AU - Boersma, Eric H
AU - Bogaty, Peter
AU - Bots, Michiel L
AU - Brenner, Hermann
AU - Brugts, Jasper J
AU - Burkhardt, Ralph
AU - Carpeggiani, Clara
AU - Condorelli, Gianluigi
AU - Cooper-DeHoff, Rhonda M
AU - Cresci, Sharon
AU - Danchin, Nicolas
AU - de Faire, Ulf
AU - Doughty, Robert N
AU - Drexel, Heinz
AU - Engert, James C
AU - Fox, Keith A A
AU - Girelli, Domenico
AU - Grobbee, Diederick E
AU - Hagström, Emil
AU - Hazen, Stanley L
AU - Held, Claes
AU - Hemingway, Harry
AU - Hoefer, Imo E
AU - Hovingh, G Kees
AU - Jabbari, Reza
AU - Johnson, Julie A
AU - Jukema, J Wouter
AU - Kaczor, Marcin P
AU - Kähönen, Mika
AU - Kettner, Jiri
AU - Kiliszek, Marek
AU - Klungel, Olaf H
AU - Lagerqvist, Bo
AU - Lambrechts, Diether
AU - Laurikka, Jari O
AU - Lehtimäki, Terho
AU - Lindholm, Daniel
AU - Mahmoodi, B K
AU - Maitland-van der Zee, Anke H
AU - McPherson, Ruth
AU - Melander, Olle
AU - Metspalu, Andres
AU - Niemcunowicz-Janica, Anna
AU - Olivieri, Oliviero
AU - Opolski, Grzegorz
AU - Palmer, Colin N
AU - Pasterkamp, Gerard
AU - Pepine, Carl J
AU - Pereira, Alexandre C
AU - Pilote, Louise
AU - Quyyumi, Arshed A
AU - Richards, A Mark
AU - Sanak, Marek
AU - Siegbahn, Agneta
AU - Simon, Tabassome
AU - Sinisalo, Juha
AU - Smith, J Gustav
AU - Spertus, John A
AU - Stender, Steen
AU - Stewart, Alexandre F R
AU - Szczeklik, Wojciech
AU - Szpakowicz, Anna
AU - Tardif, Jean-Claude
AU - Ten Berg, Jurriën M
AU - Tfelt-Hansen, Jacob
AU - Thanassoulis, George
AU - Thiery, Joachim
AU - Torp-Pedersen, Christian
AU - van der Graaf, Yolanda
AU - Visseren, Frank L J
AU - Waltenberger, Johannes
AU - Weeke, Peter E
AU - Van der Harst, Pim
AU - Lang, Chim C
AU - Sattar, Naveed
AU - Cameron, Vicky A
AU - Anderson, Jeffrey L
AU - Brophy, James M
AU - Pare, Guillaume
AU - Horne, Benjamin D
AU - März, Winfried
AU - Wallentin, Lars
AU - Samani, Nilesh J
AU - Hingorani, Aroon D
AU - Asselbergs, Folkert W
PY - 2019/4
Y1 - 2019/4
N2 - BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
AB - BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
U2 - 10.1161/CIRCGEN.119.002470
DO - 10.1161/CIRCGEN.119.002470
M3 - Journal article
VL - 12
SP - e002470
JO - Circulation. Genomic and precision medicine
JF - Circulation. Genomic and precision medicine
SN - 2574-8300
IS - 4
ER -
ID: 59123651