Harvard
Biyik, KZ, Tideman, JWL, Polling, JR, Buitendijk, GHS, Jaddoe, VVW
, Larsen, M & Klaver, CCW 2020, '
Subfoveal choroidal thickness at age 9 years in relation to clinical and perinatal characteristics in the population-based Generation R Study'
Acta Ophthalmologica, bind 98, nr. 2, s. 172-176.
https://doi.org/10.1111/aos.14178
APA
Biyik, K. Z., Tideman, J. W. L., Polling, J. R., Buitendijk, G. H. S., Jaddoe, V. V. W.
, Larsen, M., & Klaver, C. C. W. (2020).
Subfoveal choroidal thickness at age 9 years in relation to clinical and perinatal characteristics in the population-based Generation R Study.
Acta Ophthalmologica,
98(2), 172-176.
https://doi.org/10.1111/aos.14178
CBE
MLA
Vancouver
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Bibtex
@article{929b791c268942d4b7e64bd973ced363,
title = "Subfoveal choroidal thickness at age 9 years in relation to clinical and perinatal characteristics in the population-based Generation R Study",
abstract = "Purpose: To assess the association between clinical and perinatal characteristics and subfoveal choroidal thickness in 9-year-old children. Methods: The study included data from the population-based Generation R cohort, whose participants underwent cycloplegic refractometry, ocular biometry, height, weight and subfoveal choroidal thickness measurements using a swept-source optical coherence tomography (SS-OCT) instrument. Birth parameters were obtained using medical records. Statistical analyses were performed using multivariate regression models adjusted for age, ethnicity and sex. Results: A total of 1018 children (52.5{\%} girls, 47.5{\%} boys) with a mean age of 9.9 ± 0.3 years and a mean cycloplegic spherical equivalent refraction of 0.80 ± 1.1 D in boys and 0.81 ± 1.4 in girls were eligible for analysis. The subfoveal choroid was 17 μm thicker in girls (298 ± 60.6 μm) than in boys (281 ± 55.0 μm; p < 0.001), a difference of 9.1 μm persisting after adjustment for age, ethnicity and axial length (p = 0.017). Subfoveal choroidal thickness decreased with increasing ocular axial length (−16.2 μm/mm, 95{\%} CI −21.2 to −12.4, p < 0.001) and with increasing myopic refraction (−10.0 μm/D, 95{\%} CI 6.8–13.1; p < 0.001, adjusted for age, ethnicity, axial length and sex) while it increased with increasing body height (1.3 μm/cm, 95{\%} CI 0.8 to 1.9, p < 0.001). Additionally, choroidal thickness increased with increasing birthweight (13.0 μm/kg; 95{\%} CI 0.006–0.020; p < 0.001) and increasing size for gestational age (8.2 μm/kg; 95{\%} CI 4.6–11.8; p < 0.001). Smoking up until the time that pregnancy became known was associated with a thinner choroid (p = 0.016). There was no detectable effect of alcohol consumption. The distributions of axial length, refraction and choroidal thickness were narrower than in older populations. Conclusion: The subfoveal choroid was thicker in girls than in boys, and higher body height, higher birthweight and larger size for gestational age were associated with a thicker subfoveal choroid. The implications of these findings for myopia development need further evaluation in longitudinal studies.",
keywords = "children, choroidal thickness, optical coherence tomography, population study",
author = "Biyik, {Kevser Zehra} and Tideman, {Jan Willem L.} and Polling, {Jan Roelof} and Buitendijk, {Gabri{\"e}lle H.S.} and Jaddoe, {Vincent V.W.} and Michael Larsen and Klaver, {Caroline C.W.}",
year = "2020",
month = "3",
day = "1",
doi = "10.1111/aos.14178",
language = "English",
volume = "98",
pages = "172--176",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell Munksgaard",
number = "2",
}
RIS
TY - JOUR
T1 - Subfoveal choroidal thickness at age 9 years in relation to clinical and perinatal characteristics in the population-based Generation R Study
AU - Biyik, Kevser Zehra
AU - Tideman, Jan Willem L.
AU - Polling, Jan Roelof
AU - Buitendijk, Gabriëlle H.S.
AU - Jaddoe, Vincent V.W.
AU - Larsen, Michael
AU - Klaver, Caroline C.W.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Purpose: To assess the association between clinical and perinatal characteristics and subfoveal choroidal thickness in 9-year-old children. Methods: The study included data from the population-based Generation R cohort, whose participants underwent cycloplegic refractometry, ocular biometry, height, weight and subfoveal choroidal thickness measurements using a swept-source optical coherence tomography (SS-OCT) instrument. Birth parameters were obtained using medical records. Statistical analyses were performed using multivariate regression models adjusted for age, ethnicity and sex. Results: A total of 1018 children (52.5% girls, 47.5% boys) with a mean age of 9.9 ± 0.3 years and a mean cycloplegic spherical equivalent refraction of 0.80 ± 1.1 D in boys and 0.81 ± 1.4 in girls were eligible for analysis. The subfoveal choroid was 17 μm thicker in girls (298 ± 60.6 μm) than in boys (281 ± 55.0 μm; p < 0.001), a difference of 9.1 μm persisting after adjustment for age, ethnicity and axial length (p = 0.017). Subfoveal choroidal thickness decreased with increasing ocular axial length (−16.2 μm/mm, 95% CI −21.2 to −12.4, p < 0.001) and with increasing myopic refraction (−10.0 μm/D, 95% CI 6.8–13.1; p < 0.001, adjusted for age, ethnicity, axial length and sex) while it increased with increasing body height (1.3 μm/cm, 95% CI 0.8 to 1.9, p < 0.001). Additionally, choroidal thickness increased with increasing birthweight (13.0 μm/kg; 95% CI 0.006–0.020; p < 0.001) and increasing size for gestational age (8.2 μm/kg; 95% CI 4.6–11.8; p < 0.001). Smoking up until the time that pregnancy became known was associated with a thinner choroid (p = 0.016). There was no detectable effect of alcohol consumption. The distributions of axial length, refraction and choroidal thickness were narrower than in older populations. Conclusion: The subfoveal choroid was thicker in girls than in boys, and higher body height, higher birthweight and larger size for gestational age were associated with a thicker subfoveal choroid. The implications of these findings for myopia development need further evaluation in longitudinal studies.
AB - Purpose: To assess the association between clinical and perinatal characteristics and subfoveal choroidal thickness in 9-year-old children. Methods: The study included data from the population-based Generation R cohort, whose participants underwent cycloplegic refractometry, ocular biometry, height, weight and subfoveal choroidal thickness measurements using a swept-source optical coherence tomography (SS-OCT) instrument. Birth parameters were obtained using medical records. Statistical analyses were performed using multivariate regression models adjusted for age, ethnicity and sex. Results: A total of 1018 children (52.5% girls, 47.5% boys) with a mean age of 9.9 ± 0.3 years and a mean cycloplegic spherical equivalent refraction of 0.80 ± 1.1 D in boys and 0.81 ± 1.4 in girls were eligible for analysis. The subfoveal choroid was 17 μm thicker in girls (298 ± 60.6 μm) than in boys (281 ± 55.0 μm; p < 0.001), a difference of 9.1 μm persisting after adjustment for age, ethnicity and axial length (p = 0.017). Subfoveal choroidal thickness decreased with increasing ocular axial length (−16.2 μm/mm, 95% CI −21.2 to −12.4, p < 0.001) and with increasing myopic refraction (−10.0 μm/D, 95% CI 6.8–13.1; p < 0.001, adjusted for age, ethnicity, axial length and sex) while it increased with increasing body height (1.3 μm/cm, 95% CI 0.8 to 1.9, p < 0.001). Additionally, choroidal thickness increased with increasing birthweight (13.0 μm/kg; 95% CI 0.006–0.020; p < 0.001) and increasing size for gestational age (8.2 μm/kg; 95% CI 4.6–11.8; p < 0.001). Smoking up until the time that pregnancy became known was associated with a thinner choroid (p = 0.016). There was no detectable effect of alcohol consumption. The distributions of axial length, refraction and choroidal thickness were narrower than in older populations. Conclusion: The subfoveal choroid was thicker in girls than in boys, and higher body height, higher birthweight and larger size for gestational age were associated with a thicker subfoveal choroid. The implications of these findings for myopia development need further evaluation in longitudinal studies.
KW - children
KW - choroidal thickness
KW - optical coherence tomography
KW - population study
UR - http://www.scopus.com/inward/record.url?scp=85070723154&partnerID=8YFLogxK
U2 - 10.1111/aos.14178
DO - 10.1111/aos.14178
M3 - Journal article
VL - 98
SP - 172
EP - 176
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 2
ER -