Subcutaneous blood flow over 24-hour periods in patients with severe leg ischaemia

K Bjerre-Jepsen, I Faris, O Henriksen, N A Lassen

3 Citationer (Scopus)


This paper describes a method for studying the clearance of 133Xenon from the subcutaneous tissue of the calf and foot over 24-h periods. The average blood flow over this period can be estimated from the clearance constant obtained. Two series of measurement of the radioactivity are made, the first 2 h after the injection of 1-2 mCi 133Xenon in saline and the second 18-24 h later. The distance between the detector and the depot is reproduced using a cylinder 20 cm long. The median washout rate of the isotope (k) in 25 patients was 2.57 X 10(-3) min-1 for the calf and 2.39 X 10(-9) min-1 for the foot. The median difference between repeated measurements in the same patient ws 0.24 X 10(-3) min-1 in the calf and 0.43 X 10(-3) min-1 in the foot. This method, which can be used to estimate the average blood flow over 24 h while the patient undertakes his normal activities, should be useful in assessing the effect of therapy on the blood flow to the limb.
TidsskriftClinical physiology (Oxford, England)
Udgave nummer5
Sider (fra-til)357-62
Antal sider6
StatusUdgivet - okt. 1982


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