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Subacute cardiac rubidium-82 positron emission tomography ((82)Rb-PET) to assess myocardial area at risk, final infarct size, and myocardial salvage after STEMI

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Stomach interference in 82Rb-PET myocardial perfusion imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Rubidium-82 PET imaging is feasible in a rat myocardial infarction model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Rubidium-82 positron emission tomography for detection of acute doxorubicin-induced cardiac effects in lymphoma patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Validation of the all-comers design: Results of the TARGET-AC substudy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Potassium Disturbances and Risk of Ventricular Fibrillation Among Patients With ST-Segment-Elevation Myocardial Infarction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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BACKGROUND: Determining infarct size and myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) is important when assessing the efficacy of new reperfusion strategies. We investigated whether rest (82)Rb-PET myocardial perfusion imaging can estimate area at risk, final infarct size, and myocardial salvage index when compared to cardiac SPECT and magnetic resonance (CMR).

METHODS: Twelve STEMI patients were injected with (99m)Tc-Sestamibi intravenously immediate prior to reperfusion. SPECT, (82)Rb-PET, and CMR imaging were performed post-reperfusion and at a 3-month follow-up. An automated algorithm determined area at risk, final infarct size, and hence myocardial salvage index.

RESULTS: SPECT, CMR, and PET were performed 2.2 ± 0.5, 34 ± 8.5, and 32 ± 24.4 h after reperfusion, respectively. Mean (± SD) area at risk were 35.2 ± 16.6%, 34.7 ± 11.3%, and 28.1 ± 16.1% of the left ventricle (LV) in SPECT, CMR, and PET, respectively, P = 0.04 for difference. Mean final infarct size estimates were 12.3 ± 15.4%, 13.7 ± 10.4%, and 11.9 ± 14.6% of the LV in SPECT, CMR, and PET imaging, respectively, P = .72. Myocardial salvage indices were 0.64 ± 0.33 (SPECT), 0.65 ± 0.20 (CMR), and 0.63 ± 0.28 (PET), (P = .78).

CONCLUSIONS: (82)Rb-PET underestimates area at risk in patients with STEMI when compared to SPECT and CMR. However, our findings suggest that PET imaging seems feasible when assessing the clinical important parameters of final infarct size and myocardial salvage index, although with great variability, in a selected STEMI population with large infarcts. These findings should be confirmed in a larger population.

OriginalsprogEngelsk
TidsskriftJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Vol/bind25
Udgave nummer3
Sider (fra-til)970-981
ISSN1071-3581
DOI
StatusUdgivet - 2018

ID: 49191790