Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Thomas Sparsø; Meena Shaheen Hussain; Knut Borch-Johnsen; Torben Jørgensen; Sten Madsbad; Torben Hansen; Oluf Pedersen; Gitte Andersen

doi:10.1016/j.ymgme.2007.06.011

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Thomas Sparsø, Meena Shaheen Hussain, Knut Borch-Johnsen, Torben Jørgensen, Sten Madsbad, Torben Hansen, Oluf Pedersen, Gitte Andersen

Endokrinologisk Afdeling

3 Citationer (Scopus)

Abstract

Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.
Udgivelsesdato: 2007-Nov

Originalsprog	Engelsk
Tidsskrift	Molecular Genetics and Metabolism
Vol/bind	92
Udgave nummer	3
Sider (fra-til)	278-82
Antal sider	4
ISSN	1096-7192
DOI	https://doi.org/10.1016/j.ymgme.2007.06.011
Status	Udgivet - 2007

Adgang til dokumentet

10.1016/j.ymgme.2007.06.011

Citationsformater

Sparsø, T., Hussain, M. S., Borch-Johnsen, K., Jørgensen, T., Madsbad, S., Hansen, T., Pedersen, O., & Andersen, G. (2007). Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites. Molecular Genetics and Metabolism, 92(3), 278-82. https://doi.org/10.1016/j.ymgme.2007.06.011

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites. / Sparsø, Thomas; Hussain, Meena Shaheen; Borch-Johnsen, Knut et al.
I: Molecular Genetics and Metabolism, Bind 92, Nr. 3, 2007, s. 278-82.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Sparsø, T, Hussain, MS, Borch-Johnsen, K, Jørgensen, T, Madsbad, S, Hansen, T, Pedersen, O & Andersen, G 2007, 'Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites', Molecular Genetics and Metabolism, bind 92, nr. 3, s. 278-82. https://doi.org/10.1016/j.ymgme.2007.06.011

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title = "Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites",

abstract = "Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.",

keywords = "Blood Glucose, Calcium-Binding Proteins, Case-Control Studies, Denmark, Diabetes Mellitus, Type 2, Dyslipidemias, Ethnic Groups, European Continental Ancestry Group, Female, Gene Frequency, Genotype, Glucose Tolerance Test, Humans, Insulin, Male, Middle Aged, Mitochondrial Proteins, Obesity, Polymorphism, Single Nucleotide",

author = "Thomas Spars{\o} and Hussain, {Meena Shaheen} and Knut Borch-Johnsen and Torben J{\o}rgensen and Sten Madsbad and Torben Hansen and Oluf Pedersen and Gitte Andersen",

year = "2007",

doi = "10.1016/j.ymgme.2007.06.011",

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AU - Sparsø, Thomas

AU - Hussain, Meena Shaheen

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Madsbad, Sten

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Andersen, Gitte

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N2 - Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.

AB - Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.

KW - Blood Glucose

KW - Calcium-Binding Proteins

KW - Case-Control Studies

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Dyslipidemias

KW - Ethnic Groups

KW - European Continental Ancestry Group

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Mitochondrial Proteins

KW - Obesity

KW - Polymorphism, Single Nucleotide

U2 - 10.1016/j.ymgme.2007.06.011

DO - 10.1016/j.ymgme.2007.06.011

M3 - Journal article

C2 - 17681849

SN - 1096-7192

VL - 92

SP - 278

EP - 282

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

IS - 3

ER -

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Abstract

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