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Region Hovedstaden - en del af Københavns Universitetshospital
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Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes

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DOI

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  • Lena Sønder Snogdal
  • Niels Grarup
  • Karina Banasik
  • Mette Wod
  • Torben Jørgensen
  • Daniel Rinse Witte
  • Torsten Lauritzen
  • Aneta Aleksandra Nielsen
  • Ivan Brandslund
  • Cramer Christensen
  • Oluf Borbye Pedersen
  • Knud Bonnet Yderstræde
  • Henning Beck-Nielsen
  • Jan Erik Henriksen
  • Torben Hansen
  • Kurt Højlund
Vis graf over relationer
Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population.
OriginalsprogEngelsk
TidsskriftB M C Medical Genetics
Vol/bind14
Udgave nummer1
Sider (fra-til)113
ISSN1471-2350
DOI
StatusUdgivet - 25 okt. 2013

ID: 40907234