TY - JOUR
T1 - Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes
AU - Snogdal, Lena Sønder
AU - Grarup, Niels
AU - Banasik, Karina
AU - Wod, Mette
AU - Jørgensen, Torben
AU - Witte, Daniel Rinse
AU - Lauritzen, Torsten
AU - Nielsen, Aneta Aleksandra
AU - Brandslund, Ivan
AU - Christensen, Cramer
AU - Pedersen, Oluf Borbye
AU - Yderstræde, Knud Bonnet
AU - Beck-Nielsen, Henning
AU - Henriksen, Jan Erik
AU - Hansen, Torben
AU - Højlund, Kurt
PY - 2013/10/25
Y1 - 2013/10/25
N2 - Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population.
AB - Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population.
U2 - 10.1186/1471-2350-14-113
DO - 10.1186/1471-2350-14-113
M3 - Journal article
C2 - 24156295
SN - 1471-2350
VL - 14
SP - 113
JO - B M C Medical Genetics
JF - B M C Medical Genetics
IS - 1
ER -