Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

Kristoffer Sølvsten Burgdorf, Camilla Helene Sandholt, Thomas Hempel Sparsø, Gitte Andersen, Daniel Rinse Witte, Torben Jørgensen, Anelli Sandbaek, Torsten Lauritzen, Thorkild I A Sørensen, Sten Madsbad, Torben Hansen, Oluf Pedersen

14 Citationer (Scopus)

Abstract

Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.
OriginalsprogEngelsk
TidsskriftEuropean journal of endocrinology / European Federation of Endocrine Societies
Vol/bind163
Udgave nummer1
Sider (fra-til)81-7
Antal sider7
DOI
StatusUdgivet - 1 jul. 2010

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