Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes

Anette P Gjesing, Aneta Aleksandra Nielsen, Ivan Brandslund, Cramer Christensen, Anneli Sandbæk, Torben Jørgensen, Daniel Rinse Witte, Amélie Bonnefond, Phillippe Froguel, Torben Hansen, Oluf Pedersen

    9 Citationer (Scopus)

    Abstract

    Single nucleotide polymorphisms (SNPs) within the gene encoding Hexokinase 1 (HK1) are associated with changes in glycated haemoglobin (HbA1c) levels. Our aim was to investigate the effect of HK1 rs7072268 on measures of glucose- and lipid-metabolism in a Danish non-diabetic population and combine the outcome of these analyses in a meta-analysis with previously published results. Furthermore, our aim was to perform a type 2 diabetes case-control analysis and meta-analysis with two previous case-control studies.
    OriginalsprogEngelsk
    TidsskriftB M C Medical Genetics
    Vol/bind12
    Sider (fra-til)99
    ISSN1471-2350
    DOI
    StatusUdgivet - 2011

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