Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes

Anette P Gjesing, Aneta Aleksandra Nielsen, Ivan Brandslund, Cramer Christensen, Anneli Sandbæk, Torben Jørgensen, Daniel Rinse Witte, Amélie Bonnefond, Phillippe Froguel, Torben Hansen, Oluf Pedersen

    10 Citationer (Scopus)

    Abstract

    Single nucleotide polymorphisms (SNPs) within the gene encoding Hexokinase 1 (HK1) are associated with changes in glycated haemoglobin (HbA1c) levels. Our aim was to investigate the effect of HK1 rs7072268 on measures of glucose- and lipid-metabolism in a Danish non-diabetic population and combine the outcome of these analyses in a meta-analysis with previously published results. Furthermore, our aim was to perform a type 2 diabetes case-control analysis and meta-analysis with two previous case-control studies.
    OriginalsprogEngelsk
    TidsskriftB M C Medical Genetics
    Vol/bind12
    Sider (fra-til)99
    ISSN1471-2350
    DOI
    StatusUdgivet - 2011

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