Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Structural asymmetry of cortical visual areas is related to ocular dominance

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{808d8b4f1604493c8624813e5183b5f7,
title = "Structural asymmetry of cortical visual areas is related to ocular dominance",
abstract = "The grey matter of the human brain is asymmetrically distributed between the cerebral hemispheres. This asymmetry includes visual areas, but its relevance to visual function is not understood. Voxel-based morphometry is a well-established technique for localization and quantification of cerebral grey matter on the basis of MR images. This method has been used previously for interhemispheric comparison, but without examining the functional implications of the identified anatomical asymmetries of the visual system. The aim of the present study was to relate anatomical interhemispheric asymmetries to asymmetries of visual function. We examined grey matter asymmetries of visual areas in a large population (n=56) of ophthalmologically and neurologically healthy individuals. We used state-of-the-art 3 T MRI and voxel-based morphometry to relate the visual parameters, (a) ocular dominance, (b) interocular difference in visual acuity and (c) visual attention (i.e. deviation on a line-bisection task), to interhemispheric differences in grey matter volume. As most visual input from one eye is processed in the contralateral hemisphere, ocular features may also depend on cerebral lateralization. Several lateralized visual areas were identified, both right>left and left>right. When correlating the asymmetries to the functional parameters, we found a significant correlation to ocular dominance (P<0.05), whereas visual acuity and visual attention showed no such relationship. The lateral occipital complex was identified to be significantly larger in the left hemisphere for right-eyed participants and vice versa. These results suggest a cerebral basis for ocular dominance.",
author = "Jensen, {Bettina H} and Anders Hougaard and Amin, {Faisal M} and Larsson, {Henrik B W} and Messoud Ashina",
year = "2015",
month = dec,
day = "2",
doi = "10.1097/WNR.0000000000000470",
language = "English",
volume = "26",
pages = "1071--6",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",
number = "17",

}

RIS

TY - JOUR

T1 - Structural asymmetry of cortical visual areas is related to ocular dominance

AU - Jensen, Bettina H

AU - Hougaard, Anders

AU - Amin, Faisal M

AU - Larsson, Henrik B W

AU - Ashina, Messoud

PY - 2015/12/2

Y1 - 2015/12/2

N2 - The grey matter of the human brain is asymmetrically distributed between the cerebral hemispheres. This asymmetry includes visual areas, but its relevance to visual function is not understood. Voxel-based morphometry is a well-established technique for localization and quantification of cerebral grey matter on the basis of MR images. This method has been used previously for interhemispheric comparison, but without examining the functional implications of the identified anatomical asymmetries of the visual system. The aim of the present study was to relate anatomical interhemispheric asymmetries to asymmetries of visual function. We examined grey matter asymmetries of visual areas in a large population (n=56) of ophthalmologically and neurologically healthy individuals. We used state-of-the-art 3 T MRI and voxel-based morphometry to relate the visual parameters, (a) ocular dominance, (b) interocular difference in visual acuity and (c) visual attention (i.e. deviation on a line-bisection task), to interhemispheric differences in grey matter volume. As most visual input from one eye is processed in the contralateral hemisphere, ocular features may also depend on cerebral lateralization. Several lateralized visual areas were identified, both right>left and left>right. When correlating the asymmetries to the functional parameters, we found a significant correlation to ocular dominance (P<0.05), whereas visual acuity and visual attention showed no such relationship. The lateral occipital complex was identified to be significantly larger in the left hemisphere for right-eyed participants and vice versa. These results suggest a cerebral basis for ocular dominance.

AB - The grey matter of the human brain is asymmetrically distributed between the cerebral hemispheres. This asymmetry includes visual areas, but its relevance to visual function is not understood. Voxel-based morphometry is a well-established technique for localization and quantification of cerebral grey matter on the basis of MR images. This method has been used previously for interhemispheric comparison, but without examining the functional implications of the identified anatomical asymmetries of the visual system. The aim of the present study was to relate anatomical interhemispheric asymmetries to asymmetries of visual function. We examined grey matter asymmetries of visual areas in a large population (n=56) of ophthalmologically and neurologically healthy individuals. We used state-of-the-art 3 T MRI and voxel-based morphometry to relate the visual parameters, (a) ocular dominance, (b) interocular difference in visual acuity and (c) visual attention (i.e. deviation on a line-bisection task), to interhemispheric differences in grey matter volume. As most visual input from one eye is processed in the contralateral hemisphere, ocular features may also depend on cerebral lateralization. Several lateralized visual areas were identified, both right>left and left>right. When correlating the asymmetries to the functional parameters, we found a significant correlation to ocular dominance (P<0.05), whereas visual acuity and visual attention showed no such relationship. The lateral occipital complex was identified to be significantly larger in the left hemisphere for right-eyed participants and vice versa. These results suggest a cerebral basis for ocular dominance.

U2 - 10.1097/WNR.0000000000000470

DO - 10.1097/WNR.0000000000000470

M3 - Journal article

C2 - 26509548

VL - 26

SP - 1071

EP - 1076

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 17

ER -

ID: 46267869