Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid

S Häussler, M Rohde, N von Neuhoff, M Nimtz, I Steinmetz

Abstract

In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.

OriginalsprogEngelsk
TidsskriftInfection and Immunity
Vol/bind71
Udgave nummer5
Sider (fra-til)2970-5
Antal sider6
ISSN0019-9567
DOI
StatusUdgivet - maj 2003
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid'. Sammen danner de et unikt fingeraftryk.

Citationsformater