Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid

S Häussler; M Rohde; N von Neuhoff; M Nimtz; I Steinmetz

doi:10.1128/IAI.71.5.2970-2975.2003

Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid

S Häussler, M Rohde, N von Neuhoff, M Nimtz, I Steinmetz

49 Citationer (Scopus)

Abstract

In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.

Originalsprog	Engelsk
Tidsskrift	Infection and Immunity
Vol/bind	71
Udgave nummer	5
Sider (fra-til)	2970-5
Antal sider	6
ISSN	0019-9567
DOI	https://doi.org/10.1128/IAI.71.5.2970-2975.2003
Status	Udgivet - maj 2003
Udgivet eksternt	Ja

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10.1128/IAI.71.5.2970-2975.2003

Citationsformater

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title = "Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid",

abstract = "In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.",

keywords = "Actins/metabolism, Animals, Burkholderia pseudomallei/pathogenicity, Cell Cycle/drug effects, Cell Line, Cytoskeleton/drug effects, Flow Cytometry, GTP Phosphohydrolases/physiology, Glycolipids/toxicity, Mice, Microscopy, Fluorescence, Phagocytosis",

author = "S H{\"a}ussler and M Rohde and {von Neuhoff}, N and M Nimtz and I Steinmetz",

year = "2003",

month = may,

doi = "10.1128/IAI.71.5.2970-2975.2003",

language = "English",

volume = "71",

pages = "2970--5",

journal = "Infection and Immunity",

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TY - JOUR

T1 - Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid

AU - Häussler, S

AU - Rohde, M

AU - von Neuhoff, N

AU - Nimtz, M

AU - Steinmetz, I

PY - 2003/5

Y1 - 2003/5

N2 - In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.

AB - In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.

KW - Actins/metabolism

KW - Animals

KW - Burkholderia pseudomallei/pathogenicity

KW - Cell Cycle/drug effects

KW - Cell Line

KW - Cytoskeleton/drug effects

KW - Flow Cytometry

KW - GTP Phosphohydrolases/physiology

KW - Glycolipids/toxicity

KW - Mice

KW - Microscopy, Fluorescence

KW - Phagocytosis

U2 - 10.1128/IAI.71.5.2970-2975.2003

DO - 10.1128/IAI.71.5.2970-2975.2003

M3 - Journal article

C2 - 12704181

SN - 0019-9567

VL - 71

SP - 2970

EP - 2975

JO - Infection and Immunity

JF - Infection and Immunity

IS - 5

ER -

Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid

Abstract

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