Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Strengthening the reporting of observational studies in epidemiology using Mendelian Randomization: the STROBE-MR statement

Publikation: Bidrag til tidsskriftReviewForskningpeer review


  1. Association of Labor Epidural Analgesia With Autism Spectrum Disorder in Children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Lipoprotein(a) levels at birth and in early childhood: The COMPARE Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Low and high pancreatic amylase is associated with pancreatic cancer and chronic pancreatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Veronika W Skrivankova
  • Rebecca C Richmond
  • Benjamin A R Woolf
  • James Yarmolinsky
  • Neil M Davies
  • Sonja A Swanson
  • Tyler J VanderWeele
  • Julian P T Higgins
  • Nicholas J Timpson
  • Niki Dimou
  • Claudia Langenberg
  • Robert M Golub
  • Elizabeth W Loder
  • Valentina Gallo
  • Anne Tybjaerg-Hansen
  • George Davey Smith
  • Matthias Egger
  • J Brent Richards
Vis graf over relationer

Importance: Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and aim to reduce potential bias from confounding and reverse causation.

Objective: To develop the STROBE-MR Statement as a stand-alone extension to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guideline for the reporting of MR studies.

Design, Setting, and Participants: The development of the STROBE-MR Statement followed the Enhancing the Quality and Transparency of Health Research (EQUATOR) framework guidance and used the STROBE Statement as a starting point to draft a checklist tailored to MR studies. The project was initiated in 2018 by reviewing the literature on the reporting of instrumental variable and MR studies. A group of 17 experts, including MR methodologists, MR study design users, developers of previous reporting guidelines, and journal editors, participated in a workshop in May 2019 to define the scope of the Statement and draft the checklist. The draft checklist was published as a preprint in July 2019 and discussed on the preprint platform, in social media, and at the 4th Mendelian Randomization Conference. The checklist was then revised based on comments, further refined through 2020, and finalized in July 2021.

Findings: The STROBE-MR checklist is organized into 6 sections (Title and Abstract, Introduction, Methods, Results, Discussion, and Other Information) and includes 20 main items and 30 subitems. It covers both 1-sample and 2-sample MR studies that assess 1 or multiple exposures and outcomes, and addresses MR studies that follow a genome-wide association study and are reported in the same article. The checklist asks authors to justify why MR is a helpful method to address the study question and state prespecified causal hypotheses. The measurement, quality, and selection of genetic variants must be described and attempts to assess validity of MR-specific assumptions should be well reported. An item on data sharing includes reporting when the data and statistical code required to replicate the analyses can be accessed.

Conclusions and Relevance: STROBE-MR provides guidelines for reporting MR studies. Improved reporting of these studies could facilitate their evaluation by editors, peer reviewers, researchers, clinicians, and other readers, and enhance the interpretation of their results.

TidsskriftJAMA - Journal of the American Medical Association
Udgave nummer16
Sider (fra-til)1614-1621
Antal sider8
StatusUdgivet - 26 okt. 2021

ID: 68617260