Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

J M Jungersted; H Scheer; M Mempel; H Baurecht; L Cifuentes; J K Høgh; Lars Hellgren; Gregor Jemec; T Agner; S Weidinger

doi:10.1111/j.1398-9995.2010.02326.x

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

J M Jungersted, H Scheer, M Mempel, H Baurecht, L Cifuentes, J K Høgh, Lars Hellgren, Gregor Jemec, T Agner, S Weidinger

Dermato- & Venerologisk Afd.

275 Citationer (Scopus)

Abstract

Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in patients with AD have been reported. Until now, no studies have analysed stratum corneum (SC) lipids combined with skin barrier parameters in subjects of known FLG genotype.

Originalsprog	Engelsk
Tidsskrift	Allergy
Vol/bind	65
Udgave nummer	7
Sider (fra-til)	911-8
Antal sider	8
ISSN	0105-4538
DOI	https://doi.org/10.1111/j.1398-9995.2010.02326.x
Status	Udgivet - 1 jul. 2010

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10.1111/j.1398-9995.2010.02326.x

Citationsformater

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title = "Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema",

abstract = "Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in patients with AD have been reported. Until now, no studies have analysed stratum corneum (SC) lipids combined with skin barrier parameters in subjects of known FLG genotype.",

author = "Jungersted, {J M} and H Scheer and M Mempel and H Baurecht and L Cifuentes and H{\o}gh, {J K} and Lars Hellgren and Gregor Jemec and T Agner and S Weidinger",

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TY - JOUR

T1 - Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

AU - Jungersted, J M

AU - Scheer, H

AU - Mempel, M

AU - Baurecht, H

AU - Cifuentes, L

AU - Høgh, J K

AU - Hellgren, Lars

AU - Jemec, Gregor

AU - Agner, T

AU - Weidinger, S

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in patients with AD have been reported. Until now, no studies have analysed stratum corneum (SC) lipids combined with skin barrier parameters in subjects of known FLG genotype.

AB - Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in patients with AD have been reported. Until now, no studies have analysed stratum corneum (SC) lipids combined with skin barrier parameters in subjects of known FLG genotype.

U2 - 10.1111/j.1398-9995.2010.02326.x

DO - 10.1111/j.1398-9995.2010.02326.x

M3 - Journal article

C2 - 20132155

SN - 0105-4538

VL - 65

SP - 911

EP - 918

JO - Allergy

JF - Allergy

IS - 7

ER -

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

Abstract

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