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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Stratification of type 2 diabetes based on routine clinical markers

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. HbA1c variability and the development of nephropathy in individuals with type 1 diabetes mellitus from Rwanda

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  2. Risk of diabetes among related and unrelated family members

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AIMS: We hypothesized that patients with dysregulated type 2 diabetes may be stratified based on routine clinical markers.

METHODS: In this retrospective cohort study, diabetes related clinical measures including age at onset, diabetes duration, HbA1c, BMI, HOMA2-β, HOMA2-IR and GAD65 autoantibodies, were used for sub-grouping patients by K-means clustering and for adjusting. Probability of diabetes complications (95% confidence interval), were calculated using logistic regression.

RESULTS: Based on baseline data from patients with type 2 diabetes (n=2,290), the cluster analysis suggested up to five sub-groups. These were primarily characterized by autoimmune β-cell failure (3%), insulin resistance with short disease duration (21%), non-autoimmune β-cell failure (22%), insulin resistance with long disease duration (32%), and presence of metabolic syndrome (22%), respectively. Retinopathy was more common in the sub-group characterized by non-autoimmune β-cell failure (52% (47.7-56.8)) compared to other sub-groups (22% (20.1-24.1)), adj. p<0.001. The prevalence of cardiovascular disease, nephropathy and neuropathy also differed between sub-groups, but significance was lost after adjustment.

CONCLUSIONS: Patients with type 2 diabetes cluster into clinically relevant sub-groups based on routine clinical markers. The prevalence of diabetes complications seems to be sub-group specific. Our data suggests the need for a tailored strategy for the treatment of type 2 diabetes.

OriginalsprogEngelsk
TidsskriftDiabetes Research and Clinical Practice
Vol/bind141
Sider (fra-til)275-283
Antal sider8
ISSN0168-8227
DOI
StatusUdgivet - jul. 2018

ID: 53789060