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Storage time of red blood cells among ICU patients with septic shock

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@article{3d40347668bf4180bde396f2d9d24df1,
title = "Storage time of red blood cells among ICU patients with septic shock",
abstract = "BACKGROUND: We aimed to describe the exposure to blood transfusions and mortality among patients with septic shock.METHODS: We did a retrospective cohort study of two cohorts - patients with septic shock registered in a Danish ICU database (2008-2010) and patients from the Transfusion Requirements in Septic Shock (TRISS) trial (2011-2013). We extracted information on blood transfusions issued to all patients. We investigated the number of patients receiving very fresh blood (less than 7 days), very old blood (more than 24 days) and blood with a mixture of storage time.RESULTS: In the Danish cohort 1637 patients were included of whom 1394 (85{\%}) received 20,239 blood units from 14 days prior the ICU admission to 90 days after; 33{\%} were transfused before, 77{\%} in the ICU and 36{\%} after ICU. The exposure to exclusively very fresh or very old blood was 3{\%} and 4{\%}, respectively. In the TRISS cohort 77{\%} of the 937 patients received 5047 RBC units; 3{\%} received exclusively very fresh and 13{\%} very old blood. The point estimate of mortality was higher among patients receiving large amounts of exclusively very fresh and very old blood, but the number of patients were very small.CONCLUSIONS: Patients with septic shock were transfused both before and after ICU. Exposure to blood of less than 7 days or more than 24 days old were limited. We were not able to detect higher mortality among the limited number of patients with septic shock transfused with very fresh or very old blood. This article is protected by copyright. All rights reserved.",
author = "Ryg{\aa}rd, {Sofie Louise} and Lars Gr{\o}nlykke and Anders Perner and Per Winkel and Theis Lange and Holst, {Lars Broks{\o}} and Johansson, {P{\"a}r I} and Anders Aneman and Thorsten Brodersen and Eva Laur{\'e}n and Henrik Ullum and J{\o}rn Wetterslev",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = "7",
day = "8",
doi = "10.1111/aas.13439",
language = "English",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell Munksgaard",

}

RIS

TY - JOUR

T1 - Storage time of red blood cells among ICU patients with septic shock

AU - Rygård, Sofie Louise

AU - Grønlykke, Lars

AU - Perner, Anders

AU - Winkel, Per

AU - Lange, Theis

AU - Holst, Lars Broksø

AU - Johansson, Pär I

AU - Aneman, Anders

AU - Brodersen, Thorsten

AU - Laurén, Eva

AU - Ullum, Henrik

AU - Wetterslev, Jørn

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/7/8

Y1 - 2019/7/8

N2 - BACKGROUND: We aimed to describe the exposure to blood transfusions and mortality among patients with septic shock.METHODS: We did a retrospective cohort study of two cohorts - patients with septic shock registered in a Danish ICU database (2008-2010) and patients from the Transfusion Requirements in Septic Shock (TRISS) trial (2011-2013). We extracted information on blood transfusions issued to all patients. We investigated the number of patients receiving very fresh blood (less than 7 days), very old blood (more than 24 days) and blood with a mixture of storage time.RESULTS: In the Danish cohort 1637 patients were included of whom 1394 (85%) received 20,239 blood units from 14 days prior the ICU admission to 90 days after; 33% were transfused before, 77% in the ICU and 36% after ICU. The exposure to exclusively very fresh or very old blood was 3% and 4%, respectively. In the TRISS cohort 77% of the 937 patients received 5047 RBC units; 3% received exclusively very fresh and 13% very old blood. The point estimate of mortality was higher among patients receiving large amounts of exclusively very fresh and very old blood, but the number of patients were very small.CONCLUSIONS: Patients with septic shock were transfused both before and after ICU. Exposure to blood of less than 7 days or more than 24 days old were limited. We were not able to detect higher mortality among the limited number of patients with septic shock transfused with very fresh or very old blood. This article is protected by copyright. All rights reserved.

AB - BACKGROUND: We aimed to describe the exposure to blood transfusions and mortality among patients with septic shock.METHODS: We did a retrospective cohort study of two cohorts - patients with septic shock registered in a Danish ICU database (2008-2010) and patients from the Transfusion Requirements in Septic Shock (TRISS) trial (2011-2013). We extracted information on blood transfusions issued to all patients. We investigated the number of patients receiving very fresh blood (less than 7 days), very old blood (more than 24 days) and blood with a mixture of storage time.RESULTS: In the Danish cohort 1637 patients were included of whom 1394 (85%) received 20,239 blood units from 14 days prior the ICU admission to 90 days after; 33% were transfused before, 77% in the ICU and 36% after ICU. The exposure to exclusively very fresh or very old blood was 3% and 4%, respectively. In the TRISS cohort 77% of the 937 patients received 5047 RBC units; 3% received exclusively very fresh and 13% very old blood. The point estimate of mortality was higher among patients receiving large amounts of exclusively very fresh and very old blood, but the number of patients were very small.CONCLUSIONS: Patients with septic shock were transfused both before and after ICU. Exposure to blood of less than 7 days or more than 24 days old were limited. We were not able to detect higher mortality among the limited number of patients with septic shock transfused with very fresh or very old blood. This article is protected by copyright. All rights reserved.

U2 - 10.1111/aas.13439

DO - 10.1111/aas.13439

M3 - Journal article

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

ER -

ID: 57626586