Harvard
Suppli, MH, Af Rosenschold, PM, Pappot, H, Dahl, B, Morgen, SS, Vogelius, IR & Engelholm, SA 2016, '
Stereotactic radiosurgery versus decompressive surgery followed by postoperative radiotherapy for metastatic spinal cord compression (STEREOCORD): Study protocol of a randomized non-inferiority trial'
Journal of radiosurgery and SBRT, bind 4, nr. 1, s. S1-S9.
APA
Suppli, M. H., Af Rosenschold, P. M., Pappot, H., Dahl, B., Morgen, S. S., Vogelius, I. R., & Engelholm, S. A. (2016).
Stereotactic radiosurgery versus decompressive surgery followed by postoperative radiotherapy for metastatic spinal cord compression (STEREOCORD): Study protocol of a randomized non-inferiority trial.
Journal of radiosurgery and SBRT,
4(1), S1-S9.
CBE
MLA
Vancouver
Author
Bibtex
@article{eb391c0a625e44b3b0383cc8cda9ed3e,
title = "Stereotactic radiosurgery versus decompressive surgery followed by postoperative radiotherapy for metastatic spinal cord compression (STEREOCORD): Study protocol of a randomized non-inferiority trial",
abstract = "Current treatment standard for patients with metastatic spinal cord compression (MSCC) is decompressive surgery followed by radiotherapy. Stereotactic radiosurgery (SRS) could be considered a treatment option for MSCC for patients with minor neurologic deficits. If SRS is safely and effectively delivered with equivalent functional outcome, the patients would avoid the risks associated with an invasive procedure. This paper presents the design of a non-inferiority clinical trial evaluating the safety, tolerability and feasibility of SRS vs. current standard treatment for patients with MSCC. Patients fulfilling inclusion criteria will be randomized 1:1 to each arm. The primary endpoint is ability to walk six weeks after treatment. Secondary endpoints are levels of pain, bladder control, quality of life, response rate, toxicity and number of treatment days. 65 patients in each arm are required for the power of 89{\%} to detect a clinically relevant inferior outcome.",
author = "Suppli, {Morten H} and {Af Rosenschold}, {Per Munck} and Helle Pappot and Benny Dahl and Morgen, {S{\o}ren S} and Vogelius, {Ivan R} and Engelholm, {Svend A}",
year = "2016",
language = "English",
volume = "4",
pages = "S1--S9",
journal = "Journal of radiosurgery and SBRT",
issn = "2156-4639",
number = "1",
}
RIS
TY - JOUR
T1 - Stereotactic radiosurgery versus decompressive surgery followed by postoperative radiotherapy for metastatic spinal cord compression (STEREOCORD)
T2 - Study protocol of a randomized non-inferiority trial
AU - Suppli, Morten H
AU - Af Rosenschold, Per Munck
AU - Pappot, Helle
AU - Dahl, Benny
AU - Morgen, Søren S
AU - Vogelius, Ivan R
AU - Engelholm, Svend A
PY - 2016
Y1 - 2016
N2 - Current treatment standard for patients with metastatic spinal cord compression (MSCC) is decompressive surgery followed by radiotherapy. Stereotactic radiosurgery (SRS) could be considered a treatment option for MSCC for patients with minor neurologic deficits. If SRS is safely and effectively delivered with equivalent functional outcome, the patients would avoid the risks associated with an invasive procedure. This paper presents the design of a non-inferiority clinical trial evaluating the safety, tolerability and feasibility of SRS vs. current standard treatment for patients with MSCC. Patients fulfilling inclusion criteria will be randomized 1:1 to each arm. The primary endpoint is ability to walk six weeks after treatment. Secondary endpoints are levels of pain, bladder control, quality of life, response rate, toxicity and number of treatment days. 65 patients in each arm are required for the power of 89% to detect a clinically relevant inferior outcome.
AB - Current treatment standard for patients with metastatic spinal cord compression (MSCC) is decompressive surgery followed by radiotherapy. Stereotactic radiosurgery (SRS) could be considered a treatment option for MSCC for patients with minor neurologic deficits. If SRS is safely and effectively delivered with equivalent functional outcome, the patients would avoid the risks associated with an invasive procedure. This paper presents the design of a non-inferiority clinical trial evaluating the safety, tolerability and feasibility of SRS vs. current standard treatment for patients with MSCC. Patients fulfilling inclusion criteria will be randomized 1:1 to each arm. The primary endpoint is ability to walk six weeks after treatment. Secondary endpoints are levels of pain, bladder control, quality of life, response rate, toxicity and number of treatment days. 65 patients in each arm are required for the power of 89% to detect a clinically relevant inferior outcome.
M3 - Journal article
VL - 4
SP - S1-S9
JO - Journal of radiosurgery and SBRT
JF - Journal of radiosurgery and SBRT
SN - 2156-4639
IS - 1
ER -