Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours

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Abstrakt

NANOG is a key regulator of embryonic stem cell (ESC) self-renewal and pluripotency. Our recent genome-wide gene expression profiling study of the precursor of testicular germ cell tumours, carcinoma in situ testis (CIS), showed close similarity between ESC and CIS, including high NANOG expression. In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens.
OriginalsprogEngelsk
TidsskriftHistopathology
Vol/bind47
Udgave nummer1
Sider (fra-til)48-56
Antal sider9
ISSN0309-0167
DOI
StatusUdgivet - 1 jul. 2005

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