Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours

C E Hoei-Hansen; K Almstrup; J E Nielsen; Si Brask Sonne; N Graem; N E Skakkebaek; H Leffers; E Rajpert-De Meyts

doi:10.1111/j.1365-2559.2005.02182.x

Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours

C E Hoei-Hansen, K Almstrup, J E Nielsen, Si Brask Sonne, N Graem, N E Skakkebaek, H Leffers, E Rajpert-De Meyts

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Abstract

NANOG is a key regulator of embryonic stem cell (ESC) self-renewal and pluripotency. Our recent genome-wide gene expression profiling study of the precursor of testicular germ cell tumours, carcinoma in situ testis (CIS), showed close similarity between ESC and CIS, including high NANOG expression. In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens.

Originalsprog	Engelsk
Tidsskrift	Histopathology
Vol/bind	47
Udgave nummer	1
Sider (fra-til)	48-56
Antal sider	9
ISSN	0309-0167
DOI	https://doi.org/10.1111/j.1365-2559.2005.02182.x
Status	Udgivet - 1 jul. 2005

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10.1111/j.1365-2559.2005.02182.x

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abstract = "NANOG is a key regulator of embryonic stem cell (ESC) self-renewal and pluripotency. Our recent genome-wide gene expression profiling study of the precursor of testicular germ cell tumours, carcinoma in situ testis (CIS), showed close similarity between ESC and CIS, including high NANOG expression. In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens.",

author = "Hoei-Hansen, {C E} and K Almstrup and Nielsen, {J E} and Sonne, {Si Brask} and N Graem and Skakkebaek, {N E} and H Leffers and {Rajpert-De Meyts}, E",

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AU - Hoei-Hansen, C E

AU - Almstrup, K

AU - Nielsen, J E

AU - Sonne, Si Brask

AU - Graem, N

AU - Skakkebaek, N E

AU - Leffers, H

AU - Rajpert-De Meyts, E

PY - 2005/7/1

Y1 - 2005/7/1

N2 - NANOG is a key regulator of embryonic stem cell (ESC) self-renewal and pluripotency. Our recent genome-wide gene expression profiling study of the precursor of testicular germ cell tumours, carcinoma in situ testis (CIS), showed close similarity between ESC and CIS, including high NANOG expression. In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens.

AB - NANOG is a key regulator of embryonic stem cell (ESC) self-renewal and pluripotency. Our recent genome-wide gene expression profiling study of the precursor of testicular germ cell tumours, carcinoma in situ testis (CIS), showed close similarity between ESC and CIS, including high NANOG expression. In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens.

U2 - 10.1111/j.1365-2559.2005.02182.x

DO - 10.1111/j.1365-2559.2005.02182.x

M3 - Journal article

C2 - 15982323

SN - 0309-0167

VL - 47

SP - 48

EP - 56

JO - Histopathology

JF - Histopathology

IS - 1

ER -

Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours

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