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STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides

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Harvard

Fredholm, SM, Gjerdrum, LM, Willerslev-Olsen, A, Petersen, DL, Nielsen, IØ, Kauczok, C-S, Wobser, M, Ralfkiær, U, Bonefeld, CM, Wasik, MA, Krejsgaard, T, Geisler, C, Ralfkiaer, E, Gniadecki, R, Woetmann, A & Odum, N 2014, 'STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides' Anticancer Research, bind 34, nr. 10, s. 5277-86.

APA

Fredholm, S. M., Gjerdrum, L. M., Willerslev-Olsen, A., Petersen, D. L., Nielsen, I. Ø., Kauczok, C-S., ... Odum, N. (2014). STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides. Anticancer Research, 34(10), 5277-86.

CBE

Fredholm SM, Gjerdrum LM, Willerslev-Olsen A, Petersen DL, Nielsen IØ, Kauczok C-S, Wobser M, Ralfkiær U, Bonefeld CM, Wasik MA, Krejsgaard T, Geisler C, Ralfkiaer E, Gniadecki R, Woetmann A, Odum N. 2014. STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides. Anticancer Research. 34(10):5277-86.

MLA

Vancouver

Fredholm SM, Gjerdrum LM, Willerslev-Olsen A, Petersen DL, Nielsen IØ, Kauczok C-S o.a. STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides. Anticancer Research. 2014 okt;34(10):5277-86.

Author

Fredholm, Simon Mayland ; Gjerdrum, Lise Mette ; Willerslev-Olsen, Andreas ; Petersen, David Leander ; Nielsen, Inger Ø. ; Kauczok, Claudia-S ; Wobser, Marion ; Ralfkiær, Ulrik ; Bonefeld, Charlotte M ; Wasik, Mariusz A ; Krejsgaard, Thorbjørn ; Geisler, Carsten ; Ralfkiaer, Elisabeth ; Gniadecki, Robert ; Woetmann, Anders ; Odum, Niels. / STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides. I: Anticancer Research. 2014 ; Bind 34, Nr. 10. s. 5277-86.

Bibtex

@article{c9a936a05fc94aba835676b26920ee80,
title = "STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides",
abstract = "Eosinophil granulocytes have been implicated in anticancer immunity but recent data indicate that eosinophils can also promote cancer. Herein, we studied eosinophils in skin lesions from 43 patients with mycosis fungoides (MF). The presence of eosinophils correlated with disease stage: 78{\%} of patients with advanced disease displayed eosinophil infiltration, whereas this was only seen in 11{\%} of patients with patches (p<0.01), and in 48{\%} of those with plaque disease. Importantly, 72{\%} of patients with positive staining for phospho-signal-transducer-and-activator-of-transcription (pY-STAT3) in malignant T-cells also stained positively for eosinophils, whereas this was only observed in 28{\%} of pY-STAT3-negative patients (p<0.01). Notably, malignant T-cells expressed eosinophilic activation and trafficking factors: High-mobility group BOX-1 protein (HMGB1) and interleukin 5 (IL5). STAT3 siRNA profoundly inhibited IL5 but not HMGB1 expression. In conclusion, these data suggest that malignant T-cells orchestrate accumulation and activation of eosinophils supporting the notion of STAT3 being a putative target for therapy.",
author = "Fredholm, {Simon Mayland} and Gjerdrum, {Lise Mette} and Andreas Willerslev-Olsen and Petersen, {David Leander} and Nielsen, {Inger {\O}.} and Claudia-S Kauczok and Marion Wobser and Ulrik Ralfki{\ae}r and Bonefeld, {Charlotte M} and Wasik, {Mariusz A} and Thorbj{\o}rn Krejsgaard and Carsten Geisler and Elisabeth Ralfkiaer and Robert Gniadecki and Anders Woetmann and Niels Odum",
note = "Copyright{\circledC} 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.",
year = "2014",
month = "10",
language = "English",
volume = "34",
pages = "5277--86",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "10",

}

RIS

TY - JOUR

T1 - STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides

AU - Fredholm, Simon Mayland

AU - Gjerdrum, Lise Mette

AU - Willerslev-Olsen, Andreas

AU - Petersen, David Leander

AU - Nielsen, Inger Ø.

AU - Kauczok, Claudia-S

AU - Wobser, Marion

AU - Ralfkiær, Ulrik

AU - Bonefeld, Charlotte M

AU - Wasik, Mariusz A

AU - Krejsgaard, Thorbjørn

AU - Geisler, Carsten

AU - Ralfkiaer, Elisabeth

AU - Gniadecki, Robert

AU - Woetmann, Anders

AU - Odum, Niels

N1 - Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

PY - 2014/10

Y1 - 2014/10

N2 - Eosinophil granulocytes have been implicated in anticancer immunity but recent data indicate that eosinophils can also promote cancer. Herein, we studied eosinophils in skin lesions from 43 patients with mycosis fungoides (MF). The presence of eosinophils correlated with disease stage: 78% of patients with advanced disease displayed eosinophil infiltration, whereas this was only seen in 11% of patients with patches (p<0.01), and in 48% of those with plaque disease. Importantly, 72% of patients with positive staining for phospho-signal-transducer-and-activator-of-transcription (pY-STAT3) in malignant T-cells also stained positively for eosinophils, whereas this was only observed in 28% of pY-STAT3-negative patients (p<0.01). Notably, malignant T-cells expressed eosinophilic activation and trafficking factors: High-mobility group BOX-1 protein (HMGB1) and interleukin 5 (IL5). STAT3 siRNA profoundly inhibited IL5 but not HMGB1 expression. In conclusion, these data suggest that malignant T-cells orchestrate accumulation and activation of eosinophils supporting the notion of STAT3 being a putative target for therapy.

AB - Eosinophil granulocytes have been implicated in anticancer immunity but recent data indicate that eosinophils can also promote cancer. Herein, we studied eosinophils in skin lesions from 43 patients with mycosis fungoides (MF). The presence of eosinophils correlated with disease stage: 78% of patients with advanced disease displayed eosinophil infiltration, whereas this was only seen in 11% of patients with patches (p<0.01), and in 48% of those with plaque disease. Importantly, 72% of patients with positive staining for phospho-signal-transducer-and-activator-of-transcription (pY-STAT3) in malignant T-cells also stained positively for eosinophils, whereas this was only observed in 28% of pY-STAT3-negative patients (p<0.01). Notably, malignant T-cells expressed eosinophilic activation and trafficking factors: High-mobility group BOX-1 protein (HMGB1) and interleukin 5 (IL5). STAT3 siRNA profoundly inhibited IL5 but not HMGB1 expression. In conclusion, these data suggest that malignant T-cells orchestrate accumulation and activation of eosinophils supporting the notion of STAT3 being a putative target for therapy.

M3 - Journal article

VL - 34

SP - 5277

EP - 5286

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 10

ER -

ID: 44704751