Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Neo-antigen specific memory T-cell responses in healthy individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Immunoprofiles of colorectal cancer from Lynch syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Arginase 1-based immune modulatory vaccines induce anti-cancer immunity and synergize with anti-PD-1 checkpoint blockade

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Lynch syndrome-associated epithelial ovarian cancer and its immunological profile

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. ABO blood types and sepsis mortality

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Edda Blümel
  • Shamaila Munir Ahmad
  • Claudia Nastasi
  • Andreas Willerslev-Olsen
  • Maria Gluud
  • Simon Fredholm
  • Tengpeng Hu
  • Bas G J Surewaard
  • Lise M Lindahl
  • Hanne Fogh
  • Sergei B Koralov
  • Lise Mette Rahbek Gjerdrum
  • Rachael A Clark
  • Lars Iversen
  • Thorbjørn Krejsgaard
  • Charlotte Menné Bonefeld
  • Carsten Geisler
  • Jürgen C Becker
  • Anders Woetmann
  • Mads Hald Andersen
  • Terkild Brink Buus
  • Niels Ødum
Vis graf over relationer

Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are associated with a favorable prognosis in CTCL. Here, we show that CD8+ T cells from both healthy donors and Sézary syndrome patients are highly susceptible to cell death induced by Staphylococcal alpha-toxin, whereas malignant T cells are not. Importantly, alpha-toxin almost completely blocks cytotoxic killing of CTCL tumor cells by peptide-specific CD8+ T cells, leading to their escape from induced cell death and continued proliferation. These findings suggest that alpha-toxin may favor the persistence of malignant CTCL cells in vivo by inhibiting CD8+ T cell cytotoxicity. Thus, we propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in CTCL.

OriginalsprogEngelsk
Artikelnummer1751561
TidsskriftOncoImmunology
Vol/bind9
Udgave nummer1
Sider (fra-til)1751561
ISSN2162-4011
DOI
StatusUdgivet - 2020

Bibliografisk note

© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

ID: 61350348