Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

Jed A Hartings; M Ross Bullock; David O Okonkwo; Lilian S Murray; Gordon D Murray; Martin Fabricius; Andrew Ir Maas; Johannes Woitzik; Oliver Sakowitz; Bruce Mathern; Bob Roozenbeek; Hester Lingsma; Jens P Dreier; Ava M Puccio; Lori A Shutter; Clemens Pahl; Anthony J Strong; Co-Operative Study on Brain Injury Depolarisations

doi:10.1016/S1474-4422(11)70243-5

Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

Jed A Hartings, M Ross Bullock, David O Okonkwo, Lilian S Murray, Gordon D Murray, Martin Fabricius, Andrew Ir Maas, Johannes Woitzik, Oliver Sakowitz, Bruce Mathern, Bob Roozenbeek, Hester Lingsma, Jens P Dreier, Ava M Puccio, Lori A Shutter, Clemens Pahl, Anthony J Strong, Co-Operative Study on Brain Injury Depolarisations

Afdeling for Hjerne- og Nerveundersøgelser

256 Citationer (Scopus)

Abstract

Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50-60% of patients after traumatic brain injury (TBI). We aimed to ascertain whether spreading depolarisations are independently associated with unfavourable neurological outcome.

Originalsprog	Engelsk
Tidsskrift	Lancet neurology
Vol/bind	10
Udgave nummer	12
Sider (fra-til)	1058-64
Antal sider	7
ISSN	1474-4422
DOI	https://doi.org/10.1016/S1474-4422(11)70243-5
Status	Udgivet - 2011

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10.1016/S1474-4422(11)70243-5

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Hartings, J. A., Bullock, M. R., Okonkwo, D. O., Murray, L. S., Murray, G. D., Fabricius, M., Maas, A. I., Woitzik, J., Sakowitz, O., Mathern, B., Roozenbeek, B., Lingsma, H., Dreier, J. P., Puccio, A. M., Shutter, L. A., Pahl, C., Strong, A. J., & Co-Operative Study on Brain Injury Depolarisations (2011). Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study. Lancet neurology, 10(12), 1058-64. https://doi.org/10.1016/S1474-4422(11)70243-5

Hartings, JA, Bullock, MR, Okonkwo, DO, Murray, LS, Murray, GD, Fabricius, M, Maas, AI, Woitzik, J, Sakowitz, O, Mathern, B, Roozenbeek, B, Lingsma, H, Dreier, JP, Puccio, AM, Shutter, LA, Pahl, C, Strong, AJ & Co-Operative Study on Brain Injury Depolarisations 2011, 'Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study', Lancet neurology, bind 10, nr. 12, s. 1058-64. https://doi.org/10.1016/S1474-4422(11)70243-5

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title = "Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study",

abstract = "Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50-60% of patients after traumatic brain injury (TBI). We aimed to ascertain whether spreading depolarisations are independently associated with unfavourable neurological outcome.",

keywords = "Adolescent, Adult, Aged, Brain Injuries, Cerebral Cortex, Electroencephalography, Female, Glasgow Outcome Scale, Humans, Male, Middle Aged, Neurons, Prognosis, Prospective Studies, Recovery of Function, Treatment Outcome",

author = "Hartings, {Jed A} and Bullock, {M Ross} and Okonkwo, {David O} and Murray, {Lilian S} and Murray, {Gordon D} and Martin Fabricius and Maas, {Andrew Ir} and Johannes Woitzik and Oliver Sakowitz and Bruce Mathern and Bob Roozenbeek and Hester Lingsma and Dreier, {Jens P} and Puccio, {Ava M} and Shutter, {Lori A} and Clemens Pahl and Strong, {Anthony J} and {Co-Operative Study on Brain Injury Depolarisations}",

year = "2011",

doi = "10.1016/S1474-4422(11)70243-5",

language = "English",

volume = "10",

pages = "1058--64",

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T1 - Spreading depolarisations and outcome after traumatic brain injury

T2 - a prospective observational study

AU - Hartings, Jed A

AU - Bullock, M Ross

AU - Okonkwo, David O

AU - Murray, Lilian S

AU - Murray, Gordon D

AU - Fabricius, Martin

AU - Maas, Andrew Ir

AU - Woitzik, Johannes

AU - Sakowitz, Oliver

AU - Mathern, Bruce

AU - Roozenbeek, Bob

AU - Lingsma, Hester

AU - Dreier, Jens P

AU - Puccio, Ava M

AU - Shutter, Lori A

AU - Pahl, Clemens

AU - Strong, Anthony J

AU - Co-Operative Study on Brain Injury Depolarisations

PY - 2011

Y1 - 2011

N2 - Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50-60% of patients after traumatic brain injury (TBI). We aimed to ascertain whether spreading depolarisations are independently associated with unfavourable neurological outcome.

AB - Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50-60% of patients after traumatic brain injury (TBI). We aimed to ascertain whether spreading depolarisations are independently associated with unfavourable neurological outcome.

KW - Adolescent

KW - Adult

KW - Aged

KW - Brain Injuries

KW - Cerebral Cortex

KW - Electroencephalography

KW - Female

KW - Glasgow Outcome Scale

KW - Humans

KW - Male

KW - Middle Aged

KW - Neurons

KW - Prognosis

KW - Prospective Studies

KW - Recovery of Function

KW - Treatment Outcome

U2 - 10.1016/S1474-4422(11)70243-5

DO - 10.1016/S1474-4422(11)70243-5

M3 - Journal article

C2 - 22056157

SN - 1474-4422

VL - 10

SP - 1058

EP - 1064

JO - Lancet neurology

JF - Lancet neurology

IS - 12

ER -

Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

Abstract

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