Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology

Jesper F Bastlund; Poul Jennum; Paul Mohapel; Silke Penschuck; William P Watson

doi:10.1111/j.1528-1167.2005.63204.x

Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology

Jesper F Bastlund, Poul Jennum, Paul Mohapel, Silke Penschuck, William P Watson

Afdeling for Hjerne- og Nerveundersøgelser

30 Citationer (Scopus)

Abstract

PURPOSE: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats.

METHODS: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) acitvity and spontaneous reoccurring seizures (SRSs).

RESULTS: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep.

CONCLUSIONS: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.

Originalsprog	Engelsk
Tidsskrift	Epilepsia
Vol/bind	46
Udgave nummer	6
Sider (fra-til)	934-8
Antal sider	5
ISSN	0013-9580
DOI	https://doi.org/10.1111/j.1528-1167.2005.63204.x
Status	Udgivet - jun. 2005

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10.1111/j.1528-1167.2005.63204.x

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title = "Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology",

abstract = "PURPOSE: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats.METHODS: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) acitvity and spontaneous reoccurring seizures (SRSs).RESULTS: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep.CONCLUSIONS: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.",

keywords = "Animals, Cerebral Cortex/physiopathology, Disease Models, Animal, Electric Wiring, Electrodes, Implanted, Electroencephalography, Epilepsy, Temporal Lobe/pathology, Hypothalamus/pathology, Male, Rats, Rats, Wistar, Seizures/etiology, Sleep Disorders, Circadian Rhythm/physiopathology, Sleep Stages/physiology",

author = "Bastlund, {Jesper F} and Poul Jennum and Paul Mohapel and Silke Penschuck and Watson, {William P}",

year = "2005",

month = jun,

doi = "10.1111/j.1528-1167.2005.63204.x",

language = "English",

volume = "46",

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TY - JOUR

T1 - Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology

AU - Bastlund, Jesper F

AU - Jennum, Poul

AU - Mohapel, Paul

AU - Penschuck, Silke

AU - Watson, William P

PY - 2005/6

Y1 - 2005/6

N2 - PURPOSE: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats.METHODS: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) acitvity and spontaneous reoccurring seizures (SRSs).RESULTS: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep.CONCLUSIONS: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.

AB - PURPOSE: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats.METHODS: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) acitvity and spontaneous reoccurring seizures (SRSs).RESULTS: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep.CONCLUSIONS: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.

KW - Animals

KW - Cerebral Cortex/physiopathology

KW - Disease Models, Animal

KW - Electric Wiring

KW - Electrodes, Implanted

KW - Electroencephalography

KW - Epilepsy, Temporal Lobe/pathology

KW - Hypothalamus/pathology

KW - Male

KW - Rats

KW - Rats, Wistar

KW - Seizures/etiology

KW - Sleep Disorders, Circadian Rhythm/physiopathology

KW - Sleep Stages/physiology

U2 - 10.1111/j.1528-1167.2005.63204.x

DO - 10.1111/j.1528-1167.2005.63204.x

M3 - Journal article

C2 - 15946334

SN - 0013-9580

VL - 46

SP - 934

EP - 938

JO - Epilepsia

JF - Epilepsia

IS - 6

ER -

Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology

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