Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration

M. Kappel*, T. D. Poulsen, M. B. Hansen, H. Galbo, B. K. Pedersen

*Corresponding author af dette arbejde
18 Citationer (Scopus)

Abstract

This study was designed to test the hypothesis that the immune changes seen during in vivo whole body hyperthermia are mediated by elevations in the plasma concentrations of either catecholamines, growth hormone or β-endorphins. Eight healthy volunteers were immersed in a hot water bath (WI; water temperature 39.5°C) for 2 h during which their rectal temperature rose to 39.5°C. In a single blind, randomized, cross-over study the stress hormone effects were blocked one at a time by administration of propranolol, somatostatin or naloxone, the results were compared to those obtained during saline infusion (control). Blood samples were collected before, at the end of 2 h of WI (body temperature 39.5°C), and 2 h later. Hormone blockade did not abolish the hyperthermia-induced recruitment of natural killer (NK) cells to the blood, and no influence was observed on the percentages or concentrations of any other subpopulations of blood mononuclear cells, except that the number of cluster designation (CD)3+ cells slightly increased after hyperthermia only in the propranolol experiment. Furthermore, the NK cell activity, both unstimulated and interferon-α or interleukin-2 stimulated, did nor differ from the control situation. It is of interest, however, that somatostatin partly abolished the hyperthermia induced increase in the neutrophil number. Based on these data and previous results showing that growth hormone infusion increases the concentration of neutrophils in the blood, it is suggested that growth hormone is at least partly responsible for hyperthermia induced neutrocytosis.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Applied Physiology and Occupational Physiology
Vol/bind77
Udgave nummer1-2
Sider (fra-til)149-156
Antal sider8
ISSN0301-5548
DOI
StatusUdgivet - dec. 1997
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration'. Sammen danner de et unikt fingeraftryk.

Citationsformater