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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Solid and papillary neoplasm of the pancreas.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

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  2. Ulcerative colitis: ultrastructure of interstitial cells in myenteric plexus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • L J Jørgensen
  • A B Hansen
  • F Burcharth
  • E Philipsen
  • T Horn
Vis graf over relationer
In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, alpha 1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.
Bidragets oversatte titelSolid and papillary neoplasm of the pancreas.
OriginalsprogEngelsk
TidsskriftUltrastructural Pathology
Vol/bind16
Udgave nummer6
Sider (fra-til)659-666
Antal sider8
ISSN0191-3123
StatusUdgivet - 1992

ID: 32529329