Abstract
In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, alpha 1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.
Bidragets oversatte titel | Solid and papillary neoplasm of the pancreas. |
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Originalsprog | Engelsk |
Tidsskrift | Ultrastructural Pathology |
Vol/bind | 16 |
Udgave nummer | 6 |
Sider (fra-til) | 659-666 |
Antal sider | 8 |
ISSN | 0191-3123 |
Status | Udgivet - 1992 |