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Sodium oxybate (Xyrem) treatment in severely sleep-deprived child with Epstein-Barr virus encephalitis with lesion of sleep-wake regulation system: a case report

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@article{a7bffffaa48240c5910d2559b71fcf9c,
title = "Sodium oxybate (Xyrem) treatment in severely sleep-deprived child with Epstein-Barr virus encephalitis with lesion of sleep-wake regulation system: a case report",
abstract = "We present the effect of exogenous sodium oxybate (GHB) in a severely tormented boy unable to sleep and unable to be anesthetized due to a lesion in the sleep initiation system involving the tracks between the ventrolateral preoptic nucleus and the reticular system. We bypassed the system by using sodium oxybate's effect on the cortical GHB and GABAB receptors involved in the initiation and maintenance of sleep.",
author = "B{\o}rresen, {Malene Landbo} and Lundstr{\o}m, {Kaare Engell} and Marianne Ifversen and Jennum, {Poul J{\o}rgen}",
note = "Copyright {\circledC} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
doi = "10.1016/j.sleep.2019.03.020",
language = "English",
volume = "62",
pages = "29--31",
journal = "Sleep Medicine",
issn = "1389-9457",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Sodium oxybate (Xyrem) treatment in severely sleep-deprived child with Epstein-Barr virus encephalitis with lesion of sleep-wake regulation system

T2 - a case report

AU - Børresen, Malene Landbo

AU - Lundstrøm, Kaare Engell

AU - Ifversen, Marianne

AU - Jennum, Poul Jørgen

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019

Y1 - 2019

N2 - We present the effect of exogenous sodium oxybate (GHB) in a severely tormented boy unable to sleep and unable to be anesthetized due to a lesion in the sleep initiation system involving the tracks between the ventrolateral preoptic nucleus and the reticular system. We bypassed the system by using sodium oxybate's effect on the cortical GHB and GABAB receptors involved in the initiation and maintenance of sleep.

AB - We present the effect of exogenous sodium oxybate (GHB) in a severely tormented boy unable to sleep and unable to be anesthetized due to a lesion in the sleep initiation system involving the tracks between the ventrolateral preoptic nucleus and the reticular system. We bypassed the system by using sodium oxybate's effect on the cortical GHB and GABAB receptors involved in the initiation and maintenance of sleep.

U2 - 10.1016/j.sleep.2019.03.020

DO - 10.1016/j.sleep.2019.03.020

M3 - Journal article

VL - 62

SP - 29

EP - 31

JO - Sleep Medicine

JF - Sleep Medicine

SN - 1389-9457

ER -

ID: 58993680