Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat

R Di Marco; G Puglisi; G Papaccio; A Nicoletti; F Patti; A Reggio; K Bendtzen; F Nicoletti

Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat

R Di Marco, G Puglisi, G Papaccio, A Nicoletti, F Patti, A Reggio, K Bendtzen, F Nicoletti

8 Citationer (Scopus)

Abstract

We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in male Lewis rats. Prophylactic treatment with fusidin, 80 or 120 mg/kg bd wt., markedly ameliorated the course of the disease in rats immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rats. The fusidin-treated, immunized rats exhibited milder mononuclear cell infiltration of brains and spinal cords than control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis.

Originalsprog	Engelsk
Tidsskrift	Multiple Sclerosis
Vol/bind	7
Udgave nummer	2
Sider (fra-til)	101-4
Antal sider	4
ISSN	1352-4585
Status	Udgivet - 1 apr. 2001

Citationsformater

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title = "Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat",

abstract = "We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in male Lewis rats. Prophylactic treatment with fusidin, 80 or 120 mg/kg bd wt., markedly ameliorated the course of the disease in rats immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rats. The fusidin-treated, immunized rats exhibited milder mononuclear cell infiltration of brains and spinal cords than control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis.",

author = "{Di Marco}, R and G Puglisi and G Papaccio and A Nicoletti and F Patti and A Reggio and K Bendtzen and F Nicoletti",

year = "2001",

month = apr,

day = "1",

language = "English",

volume = "7",

pages = "101--4",

journal = "Multiple Sclerosis",

issn = "1352-4585",

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TY - JOUR

T1 - Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat

AU - Di Marco, R

AU - Puglisi, G

AU - Papaccio, G

AU - Nicoletti, A

AU - Patti, F

AU - Reggio, A

AU - Bendtzen, K

AU - Nicoletti, F

PY - 2001/4/1

Y1 - 2001/4/1

N2 - We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in male Lewis rats. Prophylactic treatment with fusidin, 80 or 120 mg/kg bd wt., markedly ameliorated the course of the disease in rats immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rats. The fusidin-treated, immunized rats exhibited milder mononuclear cell infiltration of brains and spinal cords than control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis.

AB - We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in male Lewis rats. Prophylactic treatment with fusidin, 80 or 120 mg/kg bd wt., markedly ameliorated the course of the disease in rats immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rats. The fusidin-treated, immunized rats exhibited milder mononuclear cell infiltration of brains and spinal cords than control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis.

M3 - Journal article

C2 - 11424629

SN - 1352-4585

VL - 7

SP - 101

EP - 104

JO - Multiple Sclerosis

JF - Multiple Sclerosis

IS - 2

ER -

Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat

Abstract

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