Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics

Anders G Holst; Siamak Saber; Massoud Houshmand; Elena V Zaklyazminskaya; Yinman Wang; Henrik Kjærulf Jensen; Lena Refsgaard; Stig Haunsø; Jesper Hastrup Svendsen; Morten S Olesen; Jacob Tfelt-Hansen

doi:10.1016/j.cjca.2011.11.011

Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics

Anders G Holst, Siamak Saber, Massoud Houshmand, Elena V Zaklyazminskaya, Yinman Wang, Henrik Kjærulf Jensen, Lena Refsgaard, Stig Haunsø, Jesper Hastrup Svendsen, Morten S Olesen, Jacob Tfelt-Hansen

19 Citationer (Scopus)

Abstrakt

Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular arrhythmias. Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS. Recent data from exome screening efforts permit better discrimination between low-frequency genetic variants and true monogenetic disease-causing variants. We aimed to screen the genes SCN1B through SCN4B, MOG1, CAV3, and KCND3 for variations in a population of SCN5A negative Danish and Iranian BrS patients, as well as research prior associations using newly released exome data.

Originalsprog	Engelsk
Tidsskrift	The Canadian journal of cardiology
Vol/bind	28
Udgave nummer	2
Sider (fra-til)	196-200
Antal sider	5
DOI	https://doi.org/10.1016/j.cjca.2011.11.011
Status	Udgivet - 2012

Adgang til dokumentet

10.1016/j.cjca.2011.11.011

Citationsformater

Holst, A. G., Saber, S., Houshmand, M., Zaklyazminskaya, E. V., Wang, Y., Jensen, H. K., Refsgaard, L., Haunsø, S., Svendsen, J. H., Olesen, M. S., & Tfelt-Hansen, J. (2012). Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics. The Canadian journal of cardiology, 28(2), 196-200. https://doi.org/10.1016/j.cjca.2011.11.011

Holst, AG, Saber, S, Houshmand, M, Zaklyazminskaya, EV, Wang, Y, Jensen, HK, Refsgaard, L, Haunsø, S , Svendsen, JH , Olesen, MS & Tfelt-Hansen, J 2012, 'Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics', The Canadian journal of cardiology, bind 28, nr. 2, s. 196-200. https://doi.org/10.1016/j.cjca.2011.11.011

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title = "Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics",

abstract = "Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular arrhythmias. Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS. Recent data from exome screening efforts permit better discrimination between low-frequency genetic variants and true monogenetic disease-causing variants. We aimed to screen the genes SCN1B through SCN4B, MOG1, CAV3, and KCND3 for variations in a population of SCN5A negative Danish and Iranian BrS patients, as well as research prior associations using newly released exome data.",

keywords = "Adult, Brugada Syndrome, Computational Biology, Female, Genetic Testing, Humans, Male, Middle Aged, Potassium, Sodium, Sodium Channels, Voltage-Gated Sodium Channel beta-1 Subunit",

author = "Holst, {Anders G} and Siamak Saber and Massoud Houshmand and Zaklyazminskaya, {Elena V} and Yinman Wang and Jensen, {Henrik Kj{\ae}rulf} and Lena Refsgaard and Stig Hauns{\o} and Svendsen, {Jesper Hastrup} and Olesen, {Morten S} and Jacob Tfelt-Hansen",

year = "2012",

doi = "10.1016/j.cjca.2011.11.011",

language = "English",

volume = "28",

pages = "196--200",

journal = "Canadian Journal of Cardiology",

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TY - JOUR

T1 - Sodium current and potassium transient outward current genes in Brugada syndrome

T2 - screening and bioinformatics

AU - Holst, Anders G

AU - Saber, Siamak

AU - Houshmand, Massoud

AU - Zaklyazminskaya, Elena V

AU - Wang, Yinman

AU - Jensen, Henrik Kjærulf

AU - Refsgaard, Lena

AU - Haunsø, Stig

AU - Svendsen, Jesper Hastrup

AU - Olesen, Morten S

AU - Tfelt-Hansen, Jacob

PY - 2012

Y1 - 2012

N2 - Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular arrhythmias. Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS. Recent data from exome screening efforts permit better discrimination between low-frequency genetic variants and true monogenetic disease-causing variants. We aimed to screen the genes SCN1B through SCN4B, MOG1, CAV3, and KCND3 for variations in a population of SCN5A negative Danish and Iranian BrS patients, as well as research prior associations using newly released exome data.

AB - Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular arrhythmias. Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS. Recent data from exome screening efforts permit better discrimination between low-frequency genetic variants and true monogenetic disease-causing variants. We aimed to screen the genes SCN1B through SCN4B, MOG1, CAV3, and KCND3 for variations in a population of SCN5A negative Danish and Iranian BrS patients, as well as research prior associations using newly released exome data.

KW - Adult

KW - Brugada Syndrome

KW - Computational Biology

KW - Female

KW - Genetic Testing

KW - Humans

KW - Male

KW - Middle Aged

KW - Potassium

KW - Sodium

KW - Sodium Channels

KW - Voltage-Gated Sodium Channel beta-1 Subunit

U2 - 10.1016/j.cjca.2011.11.011

DO - 10.1016/j.cjca.2011.11.011

M3 - Journal article

C2 - 22284586

VL - 28

SP - 196

EP - 200

JO - Canadian Journal of Cardiology

JF - Canadian Journal of Cardiology

SN - 0828-282X

IS - 2

ER -

Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics

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