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Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia

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@article{1608a8da1e2e483ba3daa41f7711a5d4,
title = "Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia",
abstract = "Post-weaning social isolation of rats produces an array of behavioral and neurochemical changes indicative of altered dopamine function. It has therefore been suggested that post-weaning social isolation mimics some aspects of schizophrenia. Here we replicate and extent these findings to include an investigation of prefrontal cortical dopamine dynamics using in vivo microdialysis. Social isolation for 12 weeks after weaning caused increased locomotor activity in response to novelty and amphetamine challenge. In vivo microdialysis experiments revealed that while social isolation did not change basal dopamine levels in the nucleus accumbens, it did cause a significant reduction of basal dopamine release in the prefrontal cortex. In addition, social isolation lead to a significantly larger dopamine response to an amphetamine challenge, in both the nucleus accumbens and the prefrontal cortex compared to group housed controls. Taken together, these results indicate that post-weaning social isolation alters dopaminergic function with changes resembling subcortical hyperdopaminergia and prefrontal hypodopaminergia similar to what has been observed in schizophrenic patients.",
keywords = "Amphetamine, Animals, Behavior, Animal, Dopamine, Dopamine Agents, Homeostasis, Microdialysis, Motor Activity, Nucleus Accumbens, Prefrontal Cortex, Rats, Schizophrenia, Social Behavior, Social Isolation",
author = "Katrine Fabricius and Bj{\"o}rn Steiniger-Brach and Lone Helboe and Anders Fink-Jensen and Gitta W{\"o}rtwein",
note = "Copyright {\circledC} 2010 ISDN. Published by Elsevier Ltd. All rights reserved.",
year = "2011",
doi = "10.1016/j.ijdevneu.2010.09.003",
language = "English",
volume = "29",
pages = "347--50",
journal = "International Journal of Developmental Neuroscience",
issn = "0736-5748",
publisher = "Pergamon",
number = "3",

}

RIS

TY - JOUR

T1 - Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia

AU - Fabricius, Katrine

AU - Steiniger-Brach, Björn

AU - Helboe, Lone

AU - Fink-Jensen, Anders

AU - Wörtwein, Gitta

N1 - Copyright © 2010 ISDN. Published by Elsevier Ltd. All rights reserved.

PY - 2011

Y1 - 2011

N2 - Post-weaning social isolation of rats produces an array of behavioral and neurochemical changes indicative of altered dopamine function. It has therefore been suggested that post-weaning social isolation mimics some aspects of schizophrenia. Here we replicate and extent these findings to include an investigation of prefrontal cortical dopamine dynamics using in vivo microdialysis. Social isolation for 12 weeks after weaning caused increased locomotor activity in response to novelty and amphetamine challenge. In vivo microdialysis experiments revealed that while social isolation did not change basal dopamine levels in the nucleus accumbens, it did cause a significant reduction of basal dopamine release in the prefrontal cortex. In addition, social isolation lead to a significantly larger dopamine response to an amphetamine challenge, in both the nucleus accumbens and the prefrontal cortex compared to group housed controls. Taken together, these results indicate that post-weaning social isolation alters dopaminergic function with changes resembling subcortical hyperdopaminergia and prefrontal hypodopaminergia similar to what has been observed in schizophrenic patients.

AB - Post-weaning social isolation of rats produces an array of behavioral and neurochemical changes indicative of altered dopamine function. It has therefore been suggested that post-weaning social isolation mimics some aspects of schizophrenia. Here we replicate and extent these findings to include an investigation of prefrontal cortical dopamine dynamics using in vivo microdialysis. Social isolation for 12 weeks after weaning caused increased locomotor activity in response to novelty and amphetamine challenge. In vivo microdialysis experiments revealed that while social isolation did not change basal dopamine levels in the nucleus accumbens, it did cause a significant reduction of basal dopamine release in the prefrontal cortex. In addition, social isolation lead to a significantly larger dopamine response to an amphetamine challenge, in both the nucleus accumbens and the prefrontal cortex compared to group housed controls. Taken together, these results indicate that post-weaning social isolation alters dopaminergic function with changes resembling subcortical hyperdopaminergia and prefrontal hypodopaminergia similar to what has been observed in schizophrenic patients.

KW - Amphetamine

KW - Animals

KW - Behavior, Animal

KW - Dopamine

KW - Dopamine Agents

KW - Homeostasis

KW - Microdialysis

KW - Motor Activity

KW - Nucleus Accumbens

KW - Prefrontal Cortex

KW - Rats

KW - Schizophrenia

KW - Social Behavior

KW - Social Isolation

U2 - 10.1016/j.ijdevneu.2010.09.003

DO - 10.1016/j.ijdevneu.2010.09.003

M3 - Journal article

VL - 29

SP - 347

EP - 350

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

SN - 0736-5748

IS - 3

ER -

ID: 34673043