Smallpox vaccination and all-cause infectious disease hospitalization: a Danish register-based cohort study

Signe Sørup; Marie Villumsen; Henrik Ravn; Christine Stabell Benn; Thorkild I A Sørensen; Peter Aaby; Tine Jess; Adam Anders Edvin Roth

doi:10.1093/ije/dyr063

Smallpox vaccination and all-cause infectious disease hospitalization: a Danish register-based cohort study

Signe Sørup, Marie Villumsen, Henrik Ravn, Christine Stabell Benn, Thorkild I A Sørensen, Peter Aaby, Tine Jess, Adam Anders Edvin Roth

53 Citationer (Scopus)

Abstract

There is growing evidence from observational studies and randomized trials in low-income countries that vaccinations have non-specific effects. Administration of live vaccines reduces overall child morbidity and mortality, presumably due to protection against non-targeted infections. In Denmark, the live vaccine against smallpox was phased out in the 1970s due to the eradication of smallpox. We used the phasing-out period to investigate the effect of smallpox vaccination on the risk of hospitalization for infections.

Originalsprog	Engelsk
Tidsskrift	International Journal of Epidemiology
Vol/bind	40
Udgave nummer	4
Sider (fra-til)	955-63
Antal sider	9
ISSN	0300-5771
DOI	https://doi.org/10.1093/ije/dyr063
Status	Udgivet - 2011

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10.1093/ije/dyr063

Citationsformater

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abstract = "There is growing evidence from observational studies and randomized trials in low-income countries that vaccinations have non-specific effects. Administration of live vaccines reduces overall child morbidity and mortality, presumably due to protection against non-targeted infections. In Denmark, the live vaccine against smallpox was phased out in the 1970s due to the eradication of smallpox. We used the phasing-out period to investigate the effect of smallpox vaccination on the risk of hospitalization for infections.",

keywords = "Adolescent, Adult, Child, Preschool, Cohort Studies, Communicable Disease Control, Communicable Diseases, Denmark, Hospitalization, Humans, Proportional Hazards Models, Registries, Risk Factors, Schools, Smallpox Vaccine, Vaccination, Young Adult",

author = "Signe S{\o}rup and Marie Villumsen and Henrik Ravn and Benn, {Christine Stabell} and S{\o}rensen, {Thorkild I A} and Peter Aaby and Tine Jess and Roth, {Adam Anders Edvin}",

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doi = "10.1093/ije/dyr063",

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T1 - Smallpox vaccination and all-cause infectious disease hospitalization

T2 - a Danish register-based cohort study

AU - Sørup, Signe

AU - Villumsen, Marie

AU - Ravn, Henrik

AU - Benn, Christine Stabell

AU - Sørensen, Thorkild I A

AU - Aaby, Peter

AU - Jess, Tine

AU - Roth, Adam Anders Edvin

PY - 2011

Y1 - 2011

N2 - There is growing evidence from observational studies and randomized trials in low-income countries that vaccinations have non-specific effects. Administration of live vaccines reduces overall child morbidity and mortality, presumably due to protection against non-targeted infections. In Denmark, the live vaccine against smallpox was phased out in the 1970s due to the eradication of smallpox. We used the phasing-out period to investigate the effect of smallpox vaccination on the risk of hospitalization for infections.

AB - There is growing evidence from observational studies and randomized trials in low-income countries that vaccinations have non-specific effects. Administration of live vaccines reduces overall child morbidity and mortality, presumably due to protection against non-targeted infections. In Denmark, the live vaccine against smallpox was phased out in the 1970s due to the eradication of smallpox. We used the phasing-out period to investigate the effect of smallpox vaccination on the risk of hospitalization for infections.

KW - Adolescent

KW - Adult

KW - Child, Preschool

KW - Cohort Studies

KW - Communicable Disease Control

KW - Communicable Diseases

KW - Denmark

KW - Hospitalization

KW - Humans

KW - Proportional Hazards Models

KW - Registries

KW - Risk Factors

KW - Schools

KW - Smallpox Vaccine

KW - Vaccination

KW - Young Adult

U2 - 10.1093/ije/dyr063

DO - 10.1093/ije/dyr063

M3 - Journal article

C2 - 21543446

SN - 0300-5771

VL - 40

SP - 955

EP - 963

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 4

ER -

Smallpox vaccination and all-cause infectious disease hospitalization: a Danish register-based cohort study

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