Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Ernesto Gargiulo, Elodie Viry, Etienne Moussay*, Jerome Paggetti*

*Corresponding author af dette arbejde
2 Citationer (Scopus)

Abstract

Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.

OriginalsprogEngelsk
Artikelnummer2127507
TidsskriftOncoImmunology
Vol/bind11
Udgave nummer1
Antal sider3
ISSN2162-4011
DOI
StatusUdgivet - 2022

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