Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Sleep-wake and melatonin pattern in craniopharyngioma patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. A role for exogenous GLP-1 in the management of postprandial hypoglycaemia after Roux-en-Y gastric bypass?

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Risk factors for hyperglycemia in pregnancy in the DALI study differ by period of pregnancy and OGTT time point

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. EJE PRIZE 2018: A gut feeling about glucagon

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Safety and convenience of once-weekly somapacitan in adult GH deficiency: a 26-week randomized, controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cardiomyopathy and kidney function in agalsidase beta-treated female Fabry patients: a pre-treatment vs. post-treatment analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Robust, ECG-based detection of Sleep-disordered breathing in large population-based cohorts

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality.

DESIGN: Cross-sectional study.

METHODS: A total of 15 craniopharyngioma patients were individually matched to healthy controls. In this study, 24-h salivary melatonin and cortisol were measured. Sleep-wake patterns were characterised by actigraphy and sleep diaries recorded for 2 weeks. Sleepiness, fatigue, sleep quality and general health were assessed by Multidimensional Fatigue Inventory, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Short-Form 36.

RESULTS: Patients had increased mental fatigue, daytime dysfunction, sleep latency and lower general health (all, P≤0.05), and they tended to have increased daytime sleepiness, general fatigue and impaired sleep quality compared with controls. The degree of hypothalamic injury was associated with an increased BMI and lower mental health (P=0.01). High BMI was associated with increased daytime sleepiness, daytime dysfunction, mental fatigue and lower mental health (all, P≤0.01). Low midnight melatonin was associated with reduced sleep time and efficiency (P≤0.03) and a tendency for increased sleepiness, impaired sleep quality and physical health. Midnight melatonin remained independently related to sleep time after adjustment for cortisol. Three different patterns of melatonin profiles were observed; normal (n=6), absent midnight peak (n=6) and phase-shifted peak (n=2). Only patients with absent midnight peak had impaired sleep quality, increased daytime sleepiness and general and mental fatigue.

CONCLUSION: Craniopharyngioma patients present with changes in circadian pattern and daytime symptoms, which may be due to the influence of the craniopharyngioma or its treatment on the hypothalamic circadian and sleep regulatory nuclei.

TidsskriftEuropean journal of endocrinology / European Federation of Endocrine Societies
Udgave nummer6
Sider (fra-til)873-84
Antal sider12
StatusUdgivet - jun. 2014

ID: 44891873