Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Long-term health and socioeconomic outcome of obstructive sleep apnea in children and adolescents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Robust, ECG-based detection of Sleep-disordered breathing in large population-based cohorts

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Long-term health and socioeconomic outcome of obstructive sleep apnea in children and adolescents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Type 1 narcolepsy/hypocretin deficiency is characterized by excessive daytime sleepiness, sleep fragmentation, and cataplexy. Short rapid eye movement (REM) latency (≤15 min) during nocturnal polysomnography (PSG) or during naps of the multiple sleep latency test (MSLT) defines a sleep-onset REM sleep period (SOREMP), a diagnostic hallmark. We hypothesized that abnormal sleep transitions other than SOREMPs can be identified in type 1 narcolepsy.

METHODS: Sleep-stage transitions (one to 10 epochs to one to five epochs of any other stage) and bout length features (one to 10 epochs) were extracted from PSGs. The first 15 min of sleep were excluded when a nocturnal SOREMP was recorded. F0.1 measures and receiver operating characteristic curves were used to identify specific (≥98%) features. A data set of 136 patients and 510 sex- and age-matched controls was used for the training. A data set of 19 cases and 708 sleep-clinic patients was used for the validation.

RESULTS: (1) ≥5 transitions from ≥5 epochs of stage N1 or W to ≥2 epochs of REM sleep, (2) ≥22 transitions from ≥3 epochs of stage N2 or N3 to ≥2 epochs of N1 or W, and (3) ≥16 bouts of ≥6 epochs of N1 or W were found to be highly specific (≥98%). Sensitivity ranged from 16% to 30%, and it did not vary substantially with and without medication or a nocturnal SOREMP. In patients taking antidepressants, nocturnal SOREMPs occurred much less frequently (16% vs. 36%, p < 0.001).

CONCLUSIONS: Increased sleep-stage transitions notably from ≥2.5 min of W/N1 into REM are specifically diagnostic for narcolepsy independent of a nocturnal SOREMP.

OriginalsprogEngelsk
TidsskriftSleep Medicine
Vol/bind16
Udgave nummer12
Sider (fra-til)1558-66
Antal sider9
ISSN1389-9457
DOI
StatusUdgivet - dec. 2015

ID: 46003151